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High Toxoplasma gondii Seropositivity among Brain Tumor Patients in Korea
27180580

Cited 6 time in Web of Science Cited 8 time in Scopus
Authors
Jung, Bong-Kwang; Song, Hyemi; Kim, Min-Jae; Cho, Jaeeun; Shin, Eun-Hee; Chai, Jong-Yil
Issue Date
2016-04
Publisher
The Korean Society for Parasitology and Tropical Medicine
Citation
KOREAN JOURNAL OF PARASITOLOGY Vol.54 No.2, pp. 201-204
Keywords
Toxoplasma gondiiseroprevalencebrain tumorELISA
Abstract
Toxoplasma gondii is an intracellular protozoan that can modulate the environment of the infected host. An unfavorable environment modulated by T. gondii in the brain includes tumor microenvironment. Literature has suggested that T. gondii infection is associated with development of brain tumors. However, in Korea, epidemiological data regarding this correlation have been scarce. In this study, in order to investigate the relationship between T. gondii infection and brain tumor development, we investigated the seroprevalence of T. gondii among 93 confirmed brain tumor patients (various histological types, including meningioma and astrocytoma) in Korea using ELISA. The results revealed that T. gondii seropositivity among brain tumor patients (18.3%) was significantly (P < 0.05) higher compared with that of healthy controls (8.6%). The seropositivity of brain tumor patients showed a significant age-tendency, i.e., higher in younger age group, compared with age-matched healthy controls (P < 0.05). In conclusion, this study supports the close relationship between T. gondii infection and incidence of brain tumors.
ISSN
0023-4001
Language
English
URI
http://hdl.handle.net/10371/116976
DOI
https://doi.org/10.3347/kjp.2016.54.2.201
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Journal Papers (저널논문_의학과)
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