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Immune adjuvant effect of a Toxoplasma gondii profilin-like protein in autologous whole-tumor-cell vaccination in mice
DC Field | Value | Language |
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dc.contributor.author | Pyo, Kyoung-Ho | - |
dc.contributor.author | Lee, You-Won | - |
dc.contributor.author | Lim, Sun Min | - |
dc.contributor.author | Shin, Eun-Hee | - |
dc.date.accessioned | 2017-04-21T02:29:57Z | - |
dc.date.available | 2017-07-27T15:22:02Z | - |
dc.date.created | 2018-09-06 | - |
dc.date.issued | 2016-11 | - |
dc.identifier.citation | Oncotarget, Vol.7 No.45, pp.74107-74119 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | https://hdl.handle.net/10371/116986 | - |
dc.description.abstract | Profilin-like protein in Toxoplasma gondii (TgPLP) is a Toll-like receptor (TLR) agonist. In this study, we investigated whether TgPLP has an adjuvant effect on immune function in autologous whole-tumor-cell vaccine (AWV) treatment. Mice vaccinated with AWV together with recombinant TgPLP protein had smaller CT26 tumors and increased survival. TgPLP treatment strongly increased the production of IL-12 through MyD88 signaling and several chemokines, including CCL5, CCL12, and XCL1, in bone marrow-derived macrophages (BMMs). In addition, TgPLP increased the phagocytosis of tumor cells by BMMs and promoted immune cell mobility on a tumor-matrigel scaffold. TgPLP triggered immune responses as demonstrated by increased expression of antigen presenting cell markers (MHC class I and II, B7.1, and B7.2) in BMMs and increased IL-12 and IFN-gamma expression in mice. Mice vaccinated with AWV and TgPLP had more immune cells (CD4(+) and CD8(+) T cells, natural killer cells, and macrophages) in the spleen and higher total IgG and IgG2a concentrations in the blood than mice vaccinated with AWV alone. These findings suggest that TgPLP is a TLR-based vaccine adjuvant that enhances antitumor immune responses during vaccination with AWV. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | Impact Journals | - |
dc.title | Immune adjuvant effect of a Toxoplasma gondii profilin-like protein in autologous whole-tumor-cell vaccination in mice | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 표경호 | - |
dc.contributor.AlternativeAuthor | 이유원 | - |
dc.contributor.AlternativeAuthor | 임선민 | - |
dc.contributor.AlternativeAuthor | 신은희 | - |
dc.identifier.doi | 10.18632/oncotarget.12316 | - |
dc.citation.journaltitle | Oncotarget | - |
dc.identifier.wosid | 000387452100127 | - |
dc.identifier.scopusid | 2-s2.0-84995785857 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201603383 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A079489 | - |
dc.description.srnd | CITE_RATE:5.008 | - |
dc.description.srnd | FILENAME:Oncotarget-Shin.pdf | - |
dc.description.srnd | DEPT_NM:의학과 | - |
dc.description.srnd | EMAIL:ehshin@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | FILEURL:https://srnd.snu.ac.kr/eXrepEIR/fws/file/9f40cedb-461f-4892-9f8f-040e189d3685/link | - |
dc.description.srnd | CONFIRM:Y | - |
dc.citation.endpage | 74119 | - |
dc.citation.number | 45 | - |
dc.citation.startpage | 74107 | - |
dc.citation.volume | 7 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Shin, Eun-Hee | - |
dc.identifier.srnd | T201603383 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | METASTATIC MELANOMA | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | LYSATE ANTIGEN | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | PHASE-I | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordAuthor | Toxoplasma gondii | - |
dc.subject.keywordAuthor | Toll-like receptor | - |
dc.subject.keywordAuthor | profilin | - |
dc.subject.keywordAuthor | antitumor | - |
dc.subject.keywordAuthor | vaccine | - |
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