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High-Resolution Snapshots of Proteasome Inhibitors In Action Revise Inhibition Paradigms and Inspire Next-Generation Inhibitor Design
High-Resolution Snapshots of Proteasome Inhibitors In Action Revise Inhibition Paradigms and Inspire Next-Generation Inhibitor Design

Cited 5 time in Web of Science Cited 6 time in Scopus
Authors
Carmony, Kimberly; Lee, Wooin; Kim, Kyung Bo
Issue Date
2016-10-11
Publisher
Wiley-VCH Verlag GmbH & Co. KGaA
Citation
CHEMBIOCHEM Vol.17 No.22, pp. 2115-2117
Keywords
drug designepoxyketoneoprozomibproteasome inhibitorsproteasome structures
Abstract
New high-resolution crystal structures reported by Schrader and colleagues refine our understanding of how peptide epoxyketone anticancer drugs inactivate their target: the human proteasome. These findings provide important clues for the design of next-generation proteasome inhibitor drugs.
ISSN
1439-4227
Language
English
URI
http://hdl.handle.net/10371/117528
DOI
https://doi.org/10.1002/cbic.201600488
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College of Pharmacy (약학대학)Dept. of Manufacturing Pharmacy (제약학과)Journal Papers (저널논문_제약학과)
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