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Preoperative cholesterol level as a new independent predictive factor of survival in patients with metastatic renal cell carcinoma treated with cyto-reductive nephrectomy
DC Field | Value | Language |
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dc.contributor.author | Lee, Hakmin | - |
dc.contributor.author | Kim, Yong June | - |
dc.contributor.author | Hwang, Eu Chang | - |
dc.contributor.author | Kang, Seok Ho | - |
dc.contributor.author | Hong, Sung-Hoo | - |
dc.contributor.author | Chung, Jinsoo | - |
dc.contributor.author | Kwon, Tae Gyun | - |
dc.contributor.author | Kwak, Cheol | - |
dc.contributor.author | Kim, Hyeon Hoe | - |
dc.contributor.author | Oh, Jong Jin | - |
dc.contributor.author | Lee, Sang Chul | - |
dc.contributor.author | Hong, Sung Kyu | - |
dc.contributor.author | Lee, Sang Eun | - |
dc.contributor.author | Byun, Seok-Soo | - |
dc.date.accessioned | 2017-06-01T00:35:46Z | - |
dc.date.available | 2017-06-01T09:43:49Z | - |
dc.date.issued | 2017-05-25 | - |
dc.identifier.citation | BMC Cancer, 17(1):364 | ko_KR |
dc.identifier.uri | 10.1186/s12885-017-3322-5 | - |
dc.identifier.uri | https://hdl.handle.net/10371/117636 | - |
dc.description.abstract | Background
The obesity and lipid metabolism were previously proposed to be related with the clinical outcomes of metastatic renal cell carcinoma (mRCC). We tried to investigate the relationship between preoperative cholesterol level (PCL) and survival outcomes in patients with mRCC. Methods We analysed the data of 244 patients initially treated with cyto-reductive nephrectomy after being diagnosed with mRCC. Patients were stratified into two groups according to the PCL cut-off level of 170mg/dL. The postoperative survival rates were compared using Kaplan-Meier analysis and the possible predictors of patients cancer-specific survival (CSS) and overall survival (OS) were tested using multivariate Cox-proportional hazard models. Results The low cholesterol group showed significantly worse postoperative CSS (p=0.013) and OS (p=0.009) than the high cholesterol group. On multivariate analysis, low PCL was revealed as an independent predictor of worse CSS (hazard ratio [HR], 2.162; 95% CI, 1.221–3.829; p=0.008) and OS (HR, 2.013; 95% CI, 1.206–3.361; p=0.007). Subsequent subgroup analysis showed that these results were maintained in the clear cell subgroup but not in the non-clear cell subgroup. Conclusion Decreased PCL was significantly correlated with worse survival outcomes in patients with mRCC treated with cytoreductive nephrectomy. The underlined mechanism is still uncharted and requires further investigation. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Renal cell carcinoma | ko_KR |
dc.subject | Cholesterol | ko_KR |
dc.subject | Survival | ko_KR |
dc.subject | Metastasis | ko_KR |
dc.subject | Hypercholesterolemia | ko_KR |
dc.title | Preoperative cholesterol level as a new independent predictive factor of survival in patients with metastatic renal cell carcinoma treated with cyto-reductive nephrectomy | ko_KR |
dc.type | SNU Journal | ko_KR |
dc.contributor.AlternativeAuthor | 이학민 | - |
dc.contributor.AlternativeAuthor | 김용준 | - |
dc.contributor.AlternativeAuthor | 황의창 | - |
dc.contributor.AlternativeAuthor | 강석호 | - |
dc.contributor.AlternativeAuthor | 정진수 | - |
dc.contributor.AlternativeAuthor | 권태균 | - |
dc.contributor.AlternativeAuthor | 곽철 | - |
dc.contributor.AlternativeAuthor | 김현회 | - |
dc.contributor.AlternativeAuthor | 오종진 | - |
dc.contributor.AlternativeAuthor | 이상철 | - |
dc.contributor.AlternativeAuthor | 홍성규 | - |
dc.contributor.AlternativeAuthor | 이상은 | - |
dc.contributor.AlternativeAuthor | 변석수 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2017-05-28T03:27:20Z | - |
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