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Radiologic findings as a determinant and no effect of macrolide resistance on clinical course of Mycoplasma pneumoniae pneumonia
DC Field | Value | Language |
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dc.contributor.author | Yoon, In Ae | - |
dc.contributor.author | Hong, Ki Bae | - |
dc.contributor.author | Lee, Hoan Jong | - |
dc.contributor.author | Yun, Ki Wook | - |
dc.contributor.author | Park, Ji Young | - |
dc.contributor.author | Choi, Young Hoon | - |
dc.contributor.author | Kim, Woo Sun | - |
dc.contributor.author | Lee, Hyunju | - |
dc.contributor.author | Eun, Byung Wook | - |
dc.contributor.author | Ahn, Young Min | - |
dc.contributor.author | Cho, Eun Young | - |
dc.contributor.author | Cho, Hwa Jin | - |
dc.contributor.author | Choi, Eun Hwa | - |
dc.date.accessioned | 2017-06-12T04:18:34Z | - |
dc.date.available | 2017-06-12T14:02:35Z | - |
dc.date.issued | 2017-06-07 | - |
dc.identifier.citation | BMC Infectious Diseases, 17(1):402 | ko_KR |
dc.identifier.uri | 10.1186/s12879-017-2500-z | - |
dc.identifier.uri | https://hdl.handle.net/10371/117675 | - |
dc.description.abstract | Background
With the emergence of macrolide resistance, concerns about the efficacy of macrolides for the treatment of Mycoplasma pneumoniae (MP) pneumonia in children have been raised. This study aimed to determine the effect of macrolide resistance on the outcome of children who were hospitalized with MP pneumonia. Methods Between 2010 and 2015, we performed culture of MP from nasopharyngeal samples obtained from children who were hospitalized with pneumonia at five hospitals in Korea. Macrolide resistance was determined by the analysis of 23S rRNA gene transition and the minimal inhibitory concentrations of four macrolides. Medical records were reviewed to analyze the clinical response to treatment with macrolides. Results MP was detected in 116 (4.8%) of the 2436 children with pneumonia. MP pneumonia was prevalent in 2011 and 2015. Of the 116 patients with MP pneumonia, 82 (70.7%) were macrolide-resistant. There were no differences in the age distribution, total duration of fever, and chest x-ray patterns between the macrolide-susceptible and macrolide-resistant groups. After macrolide initiation, mean days to defervescence were longer in the macrolide-resistant group than in macrolide-susceptible group (5.7days vs. 4.1days, P=0.021). However, logistic regression analysis revealed that the presence of extrapulmonary signs (P=0.039), homogeneous lobar consolidation (P=0.004), or parapneumonic effusion (P<0.001) were associated with fever duration of ≥7days after the initiation of macrolides, regardless of macrolide resistance. Conclusions This study demonstrated that fever duration in MP pneumonia was determined by the radiologic findings of chest x-ray, not by the presence of macrolide resistance. The results highlight the need for future studies to assess therapeutic benefit from macrolides in the treatment of children with MP pneumonia. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Mycoplasma pneumoniae | ko_KR |
dc.subject | Pneumonia | ko_KR |
dc.subject | Macrolides | ko_KR |
dc.subject | Resistance | ko_KR |
dc.subject | Radiologic findings | ko_KR |
dc.title | Radiologic findings as a determinant and no effect of macrolide resistance on clinical course of Mycoplasma pneumoniae pneumonia | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 윤인애 | - |
dc.contributor.AlternativeAuthor | 홍기배 | - |
dc.contributor.AlternativeAuthor | 이환종 | - |
dc.contributor.AlternativeAuthor | 윤기욱 | - |
dc.contributor.AlternativeAuthor | 박지영 | - |
dc.contributor.AlternativeAuthor | 최영훈 | - |
dc.contributor.AlternativeAuthor | 김우선 | - |
dc.contributor.AlternativeAuthor | 이현주 | - |
dc.contributor.AlternativeAuthor | 은병욱 | - |
dc.contributor.AlternativeAuthor | 안영민 | - |
dc.contributor.AlternativeAuthor | 조은영 | - |
dc.contributor.AlternativeAuthor | 조화진 | - |
dc.contributor.AlternativeAuthor | 최은화 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2017-06-11T03:16:32Z | - |
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