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Neogenin expression may be inversely correlated to the tumorigenicity of human breast cancer

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dc.contributor.authorLee, Jeong Eon-
dc.contributor.authorKim, Hee Joung-
dc.contributor.authorBae, Ji Yeon-
dc.contributor.authorKim, Seok Won-
dc.contributor.authorPark, Joon-Suk-
dc.contributor.authorShin, Hyuk Jai-
dc.contributor.authorHan, Wonshik-
dc.contributor.authorKim, Sung-Won-
dc.contributor.authorKang, Kyung-Sun-
dc.contributor.authorNoh, Dong-Young-
dc.date.accessioned2009-11-09T22:54:26Z-
dc.date.available2009-11-09T22:54:26Z-
dc.date.issued2005-12-06-
dc.identifier.citationBMC Cancer. 2005 Dec 3;5:154en
dc.identifier.issn1471-2407 (Electronic)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16324219-
dc.identifier.urihttp://hdl.handle.net/10371/11786-
dc.description.abstractBACKGROUND: Neogenin is expressed in cap cells that have been suggested to be mammary stem or precursor cells. Neogenin is known to play an important role in mammary morphogenesis; however its relationship to tumorigenesis remains to be elucidated. METHODS: To compare the expression levels of neogenin in cells with different tumorigenicity, the expression levels in M13SV1, M13SV1R2 and M13SV1R2N1 cells, which are immortalized derivatives of type I human breast epithelial cells, were evaluated. Then we measured the expression level of neogenin in paired normal and cancer tissues from eight breast cancer patients. Tissue array analysis was performed for 54 human breast tissue samples with different histology, and the results were divided into four categories (none, weak, moderate, strong) by a single well-trained blinded pathologist and statistically analyzed. RESULTS: The nontumorigenic M13SV1 cells and normal tissues showed stronger expression of neogenin than the M13SV1R2N1 cells and the paired cancer tissues. In the tissue array, all (8/8) of the normal breast tissues showed strong neogenin expression, while 93.5% (43/46) of breast cancer tissues had either no expression or only moderate levels of neogenin expression. There was a significant difference, in the expression level of neogenin, in comparisons between normal and infiltrating ductal carcinoma (p < 0.001). CONCLUSION: Neogenin may play a role in mammary carcinogenesis as well as morphogenesis, and the expression may be inversely correlated with mammary carcinogenicity. The value of neogenin as a potential prognostic factor needs further evaluation.en
dc.language.isoen-
dc.publisherBioMed Centralen
dc.subjectBlotting, Westernen
dc.subjectBreast/*metabolism/pathologyen
dc.subjectBreast Neoplasms/*metabolism/*pathologyen
dc.subjectCell Lineen
dc.subjectCell Line, Tumoren
dc.subjectEpithelial Cells/metabolismen
dc.subject*Gene Expression Regulation, Neoplasticen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectMembrane Proteins/*biosynthesisen
dc.subjectModels, Statisticalen
dc.subjectNeoplasm Metastasisen
dc.subjectPrognosisen
dc.subjectTissue Distributionen
dc.subjectTumor Markers, Biological/biosynthesisen
dc.titleNeogenin expression may be inversely correlated to the tumorigenicity of human breast canceren
dc.typeArticleen
dc.contributor.AlternativeAuthor이정언-
dc.contributor.AlternativeAuthor김희중-
dc.contributor.AlternativeAuthor배지연-
dc.contributor.AlternativeAuthor김석원-
dc.contributor.AlternativeAuthor박준석-
dc.contributor.AlternativeAuthor신혁재-
dc.contributor.AlternativeAuthor한원식-
dc.contributor.AlternativeAuthor김성원-
dc.contributor.AlternativeAuthor강경선-
dc.contributor.AlternativeAuthor노동영-
dc.identifier.doi10.1186/1471-2407-5-154-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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