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Coding single nucleotide polymorphism in the high-affinity immunoglobulin E receptor b chain (FcepsilonRI-beta) gene is associated with immunoglobulin E receptor-mediated histamine release from basophils
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Y-K | - |
dc.contributor.author | Oh, S-Y | - |
dc.contributor.author | Oh, H-B | - |
dc.contributor.author | Chun, S-Y | - |
dc.contributor.author | Cho, S-H | - |
dc.contributor.author | Koh, Y-Y | - |
dc.contributor.author | Min, K-U | - |
dc.contributor.author | Kim, Y-Y | - |
dc.date.accessioned | 2009-11-09T23:17:32Z | - |
dc.date.available | 2009-11-09T23:17:32Z | - |
dc.date.issued | 2002-05-08 | - |
dc.identifier.citation | Clin Exp Allergy. 2002 May;32(5):751-5. | en |
dc.identifier.issn | 0954-7894 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11994101 | - |
dc.identifier.uri | https://hdl.handle.net/10371/11792 | - |
dc.description.abstract | BACKGROUND: Our previous work on linkage analysis showed that histamine release from basophils to anti-IgE stimuli was linked to the gene marker of chromosome 11q13, where the beta chain of the high-affinity receptor for IgE (FcepsilonRI-beta) is located. OBJECTIVE: To evaluate the association between FcepsilonRI-mediated histamine release from basophils and four bi-allelic single nucleotide polymorphisms of the FcepsilonRI-beta gene. METHODS: Phenotypes of asthma, such as maximal histamine release from basophils and atopy, were measured from 80 randomly recruited asthmatic children. Polymorphisms of the FcepsilonRI-beta gene were determined by PCR-based methods. RESULTS: The polymorphism in exon 7, resulting in Glu to Gly substitution, was significantly associated with histamine release from basophils to anti-IgE stimuli, but not with total IgE levels and skin test responses to aeroallergens. CONCLUSION: This study supports a role for the FcepsilonRI-beta gene in the expression of high affinity IgE receptor-mediated histamine release from basophils. | en |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing | en |
dc.subject | Adolescent | en |
dc.subject | Alleles | en |
dc.subject | Asthma/*genetics | en |
dc.subject | Basophils/*immunology/metabolism | en |
dc.subject | Calcimycin/pharmacology | en |
dc.subject | Child | en |
dc.subject | Female | en |
dc.subject | Histamine Release/drug effects/physiology | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Polymorphism, Single Nucleotide | en |
dc.subject | Random Allocation | en |
dc.subject | Receptors, IgE/*genetics/*physiology | en |
dc.title | Coding single nucleotide polymorphism in the high-affinity immunoglobulin E receptor b chain (FcepsilonRI-beta) gene is associated with immunoglobulin E receptor-mediated histamine release from basophils | en |
dc.type | Article | en |
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