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Comparative outcomes of reduced intensity and myeloablative allogeneic hematopoietic stem cell transplantation in patients under 50 with hematologic malignancies
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Inho | - |
dc.contributor.author | Yoon, Sung Soo | - |
dc.contributor.author | Lee, Kyung-Hun | - |
dc.contributor.author | Keam, Bhumsuk | - |
dc.contributor.author | Kim, Tae Min | - |
dc.contributor.author | Kim, Jin-Soo | - |
dc.contributor.author | Kim, Hoon-Gu | - |
dc.contributor.author | Oh, Myoung-Don | - |
dc.contributor.author | Han, Kyou-Sup | - |
dc.contributor.author | Park, Myoung Hee | - |
dc.contributor.author | Park, Seonyang | - |
dc.contributor.author | Kim, Byoung Kook | - |
dc.date.accessioned | 2009-11-11T03:07:46Z | - |
dc.date.available | 2009-11-11T03:07:46Z | - |
dc.date.issued | 2006-07-18 | - |
dc.identifier.citation | Clin Transplant. 2006 Jul-Aug;20(4):496-503. | en |
dc.identifier.issn | 0902-0063 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16842528 | - |
dc.identifier.uri | https://hdl.handle.net/10371/11878 | - |
dc.description.abstract | We have conducted a direct comparison of the outcomes of reduced intensity and myeloablative conditioning in younger adults with hematological malignancies<50 yr. One hundred and five patients received transplants from human leukocyte antigen (HLA)-matched donors, via either reduced intensity (n=35) or myeloablative conditioning (n=70). The median ages of the reduced intensity and myeloablative groups were 36 and 33 yr (p=0.014). Neutrophil engraftment (i.e. time to absolute neutrophil count>0.5x10(9)/L) occurred more rapidly in the reduced intensity group (median: 10 d; range: 0-21 d) than in the myeloablative group (median: 18 d; range: 11-38 d; p<0.0001). The incidence of grades 2-4 acute graft-vs.-host disease were similar between the reduced intensity and myeloablative groups, at 17% vs. 24% respectively (p=0.40). The cumulative incidence of day 100 non-relapse mortality was 18% in the reduced intensity group, and 21% in the myeloablative group (p=0.88). The overall two-yr survival rates were 43% in the reduced intensity group, and 35% in the myeloablative group (p=0.72). In conclusion, reduced intensity transplantation yielded outcomes comparable with those of myeloablative transplantation in patients under 50 with hematological malignancies. | en |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing | en |
dc.subject | Adult | en |
dc.subject | Antineoplastic Combined Chemotherapy Protocols/therapeutic use | en |
dc.subject | Female | en |
dc.subject | Graft vs Host Disease | en |
dc.subject | Hematologic Neoplasms/mortality/*therapy | en |
dc.subject | Hematopoietic Stem Cell Transplantation/*methods | en |
dc.subject | Histocompatibility Testing | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Melphalan/administration & dosage | en |
dc.subject | Middle Aged | en |
dc.subject | Survival Analysis | en |
dc.subject | Transplantation Conditioning | en |
dc.subject | Transplantation, Homologous/*physiology | en |
dc.subject | Treatment Outcome | en |
dc.title | Comparative outcomes of reduced intensity and myeloablative allogeneic hematopoietic stem cell transplantation in patients under 50 with hematologic malignancies | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김인호 | - |
dc.contributor.AlternativeAuthor | 윤성수 | - |
dc.contributor.AlternativeAuthor | 이경훈 | - |
dc.contributor.AlternativeAuthor | 김범석 | - |
dc.contributor.AlternativeAuthor | 김태민 | - |
dc.contributor.AlternativeAuthor | 김진수 | - |
dc.contributor.AlternativeAuthor | 김훈구 | - |
dc.contributor.AlternativeAuthor | 오명돈 | - |
dc.contributor.AlternativeAuthor | 한규섭 | - |
dc.contributor.AlternativeAuthor | 박명희 | - |
dc.contributor.AlternativeAuthor | 박선양 | - |
dc.contributor.AlternativeAuthor | 김병국 | - |
dc.identifier.doi | 10.1111/j.1399-0012.2006.00512.x | - |
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