Browse

cag pathogenicity island of Helicobacter pylori in Korean children

DC Field Value Language
dc.contributor.authorKo, Jae Sung-
dc.contributor.authorSeo, Jeong Kee-
dc.date.accessioned2009-11-11T03:11:42Z-
dc.date.available2009-11-11T03:11:42Z-
dc.date.issued2002-08-08-
dc.identifier.citationHelicobacter. 2002 Aug;7(4):232-6.en
dc.identifier.issn1083-4389 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12165030-
dc.identifier.urihttps://hdl.handle.net/10371/11882-
dc.description.abstractBACKGROUND: cag pathogenicity island is reported to be a major virulence factor of Helicobacter pylori. The aim of this study was to investigate the status of cag pathogenicity island genes and gastric histology in Korean children with H. pylori gastritis. METHODS: Helicobacter pylori DNA was extracted from antral biopsy specimens from 25 children with H. pylori gastritis. Specific polymerase chain reaction assays were used for four genes of cag pathogenicity island. The features of gastritis were scored in accordance with the updated Sydney System. RESULTS: cagA was present in 23 (92%) of 25 children, and cagE in 24 (96%). Twenty-two (88%) children were cagT positive and 19 (76%) virD4 positive. All of the selected genes of the cag pathogenicity island were present in 17 (68%) children and completely deleted in one child. There were no differences in neutrophil activity and chronic inflammation between children infected with intact cag pathogenicity island strains and those with partially or totally deleted-cag pathogenicity island strains. CONCLUSION: cag pathogenicity island is not a uniform, conserved entity in Korea. Completeness of cag pathogenicity island may not be the major factor to determine the severity of H. pylori gastritis in children.en
dc.language.isoenen
dc.publisherBlackwell Publishingen
dc.subjectAdolescenten
dc.subject*Antigens, Bacterialen
dc.subjectBacterial Proteins/*genetics/metabolismen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectDNA, Bacterial/analysisen
dc.subjectFemaleen
dc.subjectGastritis/microbiology/*pathology/*physiopathologyen
dc.subjectHelicobacter Infections/*microbiology/pathology/physiopathologyen
dc.subjectHelicobacter pylori/genetics/*pathogenicityen
dc.subjectHumansen
dc.subjectKoreaen
dc.subjectMaleen
dc.subjectPolymerase Chain Reactionen
dc.subjectSeverity of Illness Indexen
dc.subjectVirulenceen
dc.titlecag pathogenicity island of Helicobacter pylori in Korean childrenen
dc.typeArticleen
dc.contributor.AlternativeAuthor고재성-
dc.contributor.AlternativeAuthor서정기-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse