S-Space College of Engineering/Engineering Practice School (공과대학/대학원) Dept. of Chemical and Biological Engineering (화학생물공학부) Theses (Ph.D. / Sc.D._화학생물공학부)
Integrated Electrochemical Sensors and Actuators for Multifunctional Surgical Endoscope and Glucose Monitoring System
다기능성 수술용 내시경과 당 모니터링 시스템을 위한 집적된 전기화학적 센서와 엑추에이터 시스템 구현
- 공과대학 화학생물공학부
- Issue Date
- 서울대학교 대학원
- Flexible electronics; Stretchable electronics; Wearable electronics; Electrochemical sensors; Endoscope; Glucose monitoring system
- 학위논문 (박사)-- 서울대학교 대학원 : 화학생물공학부, 2016. 8. 현택환.
- Over the past decade, flexible and stretchable electronics have achieved remarkable progress with regard to materials, designs, and manufacturing processes for biomedical applications. The electronics resolve the intrinsic mechanical mismatch between the devices and soft/curvilinear biological substrates. This enables a wide range of applications in noninvasive, minimally invasive, and wearable devices. This dissertation includes two examples of multifunctional, flexible, and stretchable electronic systems for biomedical applications, especially in dealing with colon cancer and diabetes.
First, the multifunctional endoscope system is introduced as a minimally invasive surgical tool for colon cancer treatment. Transparent bioelectronics based on a graphene hybrid are fabricated for impedance- and pH-based colon cancer detection. Bioelectronics can ablate colon cancer by using radio frequency as a feedback therapy. The bioelectronics placed in the endoscope can provide both characterization and treatment of colon cancer without optical hindrance.
Second, wearable and/or disposable sweat monitoring devices with microneedle-based transdermal drug delivery devices are developed for noninvasive blood glucose control. The glucose in sweat is correlated with the glucose in blood, which enables sweat-based blood glucose monitoring. The sensors monitor the sweat glucose concentration with a correction based on pH, temperature, and humidity measurements for accurate sensing. A thermoresponsive microneedle with drug loading is integrated for controlled transdermal drug delivery when hypoglycemia occurs.
The dissertation herein provides two representative examples of a multifunctional system as the basis for a closed-loop solution from disease monitoring to treatment. In-vitro, ex-vivo, and in-vivo experiments highlight the utility of the demonstrated technologies for colon cancer and diabetes treatment.