Proliposomes: Applications and Improvements

Abstract

The objective of this work was the development of novel applications and production methods of proliposomes. This drug delivery system offers a variety of advantages when compared to conventional liposomal formulations. Among them the ability to form liposomes upon resuspension, making dry formulation possible. This would be interesting for the formulation of unstable drugs. This approach was explored in PART I with the formulation of AAPE for topical delivery. Another advantage is the ability to promote the solubilization of otherwise low solubility drugs. Despite these advantages proliposomes also face challenges. Prime among these the low total drug content due to the need for a carrier material. These aspects, a low solubility drug (Itraconazole) and a method to increase the total drug content, were explored in PART II of this work.