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지역약국 약사의 자발적 보고 자료를 대상으로 한 약물이상반응에 관한 연구 : Spontaneous Reporting of Adverse Drug Reactions by Community Pharmacists in Korea
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 신완균 | - |
dc.contributor.author | 유윤미 | - |
dc.date.accessioned | 2017-07-13T16:36:21Z | - |
dc.date.available | 2017-07-13T16:36:21Z | - |
dc.date.issued | 2015-08 | - |
dc.identifier.other | 000000066635 | - |
dc.identifier.uri | https://hdl.handle.net/10371/120104 | - |
dc.description | 학위논문 (박사)-- 서울대학교 대학원 : 약학과 예방·임상약학전공, 2015. 8. 신완균. | - |
dc.description.abstract | Purpose: To evaluate the clinical manifestations and causative drugs associated with adverse drug reactions (ADRs) spontaneously reported by community pharmacists and to compare the ADRs by age.
Methods: ADRs reported to the Regional Pharmacovigilance Center of the Korean Pharmaceutical Association by community pharmacists from January 2013 to June 2014 were included. Causality was assessed using the WHO-Uppsala Monitoring Centre system. The patient population was classified into three age groups. We analyzed 31,398 (74.9%) ADRs from 9,705 patients, identified as having a causal relationship, from a total pool of 41,930 ADRs from 9,873 patients. Median patient age was 58.0 years | - |
dc.description.abstract | 66.9% were female.
Results: Gastrointestinal system (34.4%), nervous system (14.4%), and psychiatric (12.1%) disorders were the most frequent symptoms. Prevalent causative drugs were those for acid-related disorders (11.4%), anti-inflammatory products (10.5%), analgesics (7.2%), and antibacterials (7.1%). Comparisons by age revealed diarrhea and antibacterials to be most commonly associated with ADRs in children (p < 0.001), whereas dizziness was prevalent in the elderly (p < 0.001). Anaphylactic reaction was the most frequent serious event (19.7%), mainly associated with cephalosporins and non-steroidal anti-inflammatory drugs. Among 612 ADRs caused by nonprescription drugs, the leading symptoms and causative drugs were skin disorders (29.6%) and non-steroidal anti-inflammatory drugs (16.2%), respectively. Conclusions: According to the community pharmacist reports, the leading clinical manifestations and causative drugs associated with ADRs in outpatients differed among age groups. | - |
dc.description.tableofcontents | ABSTRACT i
TABLE OF CONTENTS iv LIST OF TABLES v LIST OF FIGURES vi INTRODUCTION 1 METHODS 5 RESULTS 10 DISCUSSION 39 CONCLUSION 45 REFERENCES 47 APPENDIX 55 국문초록 75 | - |
dc.format | application/pdf | - |
dc.format.extent | 1013444 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | 약물이상반응 | - |
dc.subject | 자발적 보고 | - |
dc.subject | 지역약국 | - |
dc.subject | 외래환자 | - |
dc.subject | 연령군 | - |
dc.subject | 약물감시활동 | - |
dc.subject.ddc | 615 | - |
dc.title | 지역약국 약사의 자발적 보고 자료를 대상으로 한 약물이상반응에 관한 연구 | - |
dc.title.alternative | Spontaneous Reporting of Adverse Drug Reactions by Community Pharmacists in Korea | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | Yun Mi Yu | - |
dc.description.degree | Doctor | - |
dc.citation.pages | vi, 79 | - |
dc.contributor.affiliation | 약학대학 약학과 | - |
dc.date.awarded | 2015-08 | - |
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