Browse

Total Syntheses of Wondonins and Isowondonins Based on a Biosynthetic Pathway
생합성 예상 경로를 기반으로 한 Wondonins과 Isowondonins의 전합성

Cited 0 time in Web of Science Cited 0 time in Scopus
Authors
ShuaiYu
Advisor
김상희
Major
약학대학 약학과
Issue Date
2016-08
Publisher
서울대학교 대학원
Keywords
AngiogenesisE/Z-Selective styryl sulfate formationRegioselective imidazole alkylationNoyori asymmetric hydrogenationTotal synthesis
Description
학위논문 (박사)-- 서울대학교 대학원 : 약학과, 2016. 8. 김상희.
Abstract
The first total syntheses of wondonins and isowondonins, which are unusual imidazole marine alkaloids, has been accomplished through the development of methods for the selective formation of styryl sulfate group and regioselective alkylation of the imidazole. Application of the Noyori asymmetric hydrogenation of ketones allows the asymmetric synthesis of isowondonins. These results in conjunction with ECD calculations led to the determination of the absolute configuration of isowondonins.
Language
English
URI
https://hdl.handle.net/10371/120142
Files in This Item:
Appears in Collections:
College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Theses (Ph.D. / Sc.D._약학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse