Total Syntheses of Wondonins and Isowondonins Based on a Biosynthetic Pathway
생합성 예상 경로를 기반으로 한 Wondonins과 Isowondonins의 전합성
- 약학대학 약학과
- Issue Date
- 서울대학교 대학원
- Angiogenesis; E/Z-Selective styryl sulfate formation; Regioselective imidazole alkylation; Noyori asymmetric hydrogenation; Total synthesis
- 학위논문 (박사)-- 서울대학교 대학원 : 약학과, 2016. 8. 김상희.
- The first total syntheses of wondonins and isowondonins, which are unusual imidazole marine alkaloids, has been accomplished through the development of methods for the selective formation of styryl sulfate group and regioselective alkylation of the imidazole. Application of the Noyori asymmetric hydrogenation of ketones allows the asymmetric synthesis of isowondonins. These results in conjunction with ECD calculations led to the determination of the absolute configuration of isowondonins.