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Association of HLA class II genes with idiopathic pulmonary arterial hypertension in Koreans

Cited 2 time in Web of Science Cited 2 time in Scopus
Authors
Yoon, Sung-Ho; Oh, Heung-Bum; Kim, Hyun-Kuk; Hong, Suk-Chan; Oh, Yeon-Mok; Lee, Dong Soon; Lee, Sang-Do
Issue Date
2007
Publisher
Springer Verlag
Citation
Lung 185: 145-149
Keywords
Gene Frequency*Genes, MHC Class II*Genetic Predisposition to DiseaseHLA-DQ Antigens/*geneticsHLA-DR Antigens/*geneticsHaplotypesRisk Factors
Abstract
The aim of this study was to compare the frequency of the HLA-DRB1 and HLA-DQB1 alleles in Korean patients with idiopathic pulmonary arterial hypertension (IPAH) and in normal controls and to determine any association that may exist between clinical characteristics of IPAH and specific HLA alleles. IPAH patients seen between October 1998 and September 2001 were retrospectively assessed, and 19 patients and 193 controls were HLA typed at the HLA-DRB1 and DQB1 loci. Clinical characteristics and hemodynamic parameters were reviewed. The patients with IPAH had a significantly higher frequency of the HLA-DRB1*0406 allele (18% vs. 6%, p = 0.004) and the HLA-DQB1*0302 allele (24% vs. 12%, p = 0.034), as well as a significantly higher frequency of haplotype DRB1*0406-DQB1*0302 (p = 0.0006). All 6 patients with haplotype DRB1*0406-DQB1*0302 (H+ group) were women, compared with 8 of the 13 patients lacking the DRB1*0406-DQB1*0302 haplotype (H- group), but without statistical significance. Three of 19 patients showed a positive short-term hemodynamic response to NO inhalation, all 3 of whom had the DRB1*0406-DQB1*0302 haplotype. There were no other significant differences in clinical characteristics and hemodynamic parameters between the H+ and H- groups. We conclude from this study that the HLA-DRB1*0406-DQB1*0302 haplotype is associated with IPAH in Korean patients. These results suggest that certain clinical characteristics of IPAH may be controlled in part by patients' HLA alleles.
ISSN
0341-2040 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17406941

https://hdl.handle.net/10371/12121
DOI
https://doi.org/10.1007/s00408-007-9006-1
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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