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Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Norman, Paul J | - |
dc.contributor.author | Abi-Rached, Laurent | - |
dc.contributor.author | Gendzekhadze, Ketevan | - |
dc.contributor.author | Korbel, Daniel | - |
dc.contributor.author | Gleimer, Michael | - |
dc.contributor.author | Rowley, Don | - |
dc.contributor.author | Bruno, Dan | - |
dc.contributor.author | Carrington, Christine V F | - |
dc.contributor.author | Chandanayingyong, Dasdayanee | - |
dc.contributor.author | Chang, Yih-Hsin | - |
dc.contributor.author | Crespi, Catalina | - |
dc.contributor.author | Saruhan-Direskeneli, Guher | - |
dc.contributor.author | Fraser, Patricia A | - |
dc.contributor.author | Hameed, Kamran | - |
dc.contributor.author | Kamkamidze, Giorgi | - |
dc.contributor.author | Koram, Kwadwo A | - |
dc.contributor.author | Layrisse, Zulay | - |
dc.contributor.author | Matamoros, Nuria | - |
dc.contributor.author | Mila, Joan | - |
dc.contributor.author | Park, Myoung Hee | - |
dc.contributor.author | Pitchappan, Ramasamy M | - |
dc.contributor.author | Ramdath, D Dan | - |
dc.contributor.author | Shiau, Ming-Yuh | - |
dc.contributor.author | Stephens, Henry A F | - |
dc.contributor.author | Struik, Siske | - |
dc.contributor.author | Verity, David H | - |
dc.contributor.author | Vaughan, Robert W | - |
dc.contributor.author | Tyan, Dolly | - |
dc.contributor.author | Davis, Ronald W | - |
dc.contributor.author | Riley, Eleanor M | - |
dc.contributor.author | Ronaghi, Mostafa | - |
dc.contributor.author | Parham, Peter | - |
dc.date.accessioned | 2009-11-13T04:25:13Z | - |
dc.date.available | 2009-11-13T04:25:13Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Nat. Genet. 39, 1092-1099 | en |
dc.identifier.issn | 1061-4036 (Print) | - |
dc.identifier.uri | http://www.nature.com/ng/journal/v39/n9/abs/ng2111.html | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17694054 | - |
dc.identifier.uri | https://hdl.handle.net/10371/12122 | - |
dc.description.abstract | Interactions of killer cell immunoglobulin-like receptors (KIRs) with major histocompatibility complex (MHC) class I ligands diversify natural killer cell responses to infection. By analyzing sequence variation in diverse human populations, we show that the KIR3DL1/S1 locus encodes two lineages of polymorphic inhibitory KIR3DL1 allotypes that recognize Bw4 epitopes of protein">HLA-A and HLA-B and one lineage of conserved activating KIR3DS1 allotypes, also implicated in Bw4 recognition. Balancing selection has maintained these three lineages for over 3 million years. Variation was selected at D1 and D2 domain residues that contact HLA class I and at two sites on D0, the domain that enhances the binding of KIR3D to HLA class I. HLA-B variants that gained Bw4 through interallelic microconversion are also products of selection. A worldwide comparison uncovers unusual KIR3DL1/S1 evolution in modern sub-Saharan Africans. Balancing selection is weak and confined to D0, KIR3DS1 is rare and KIR3DL1 allotypes with similar binding sites predominate. Natural killer cells express the dominant KIR3DL1 at a high frequency and with high surface density, providing strong responses to cells perturbed in Bw4 expression. | en |
dc.language.iso | en | en |
dc.publisher | Nature Publishing Group | en |
dc.subject | African Continental Ancestry Group/*genetics | en |
dc.subject | Alleles | en |
dc.subject | Amino Acid Sequence | en |
dc.subject | Binding Sites/genetics | en |
dc.subject | Gene Frequency | en |
dc.subject | Genetics, Population | en |
dc.subject | HLA-B Antigens/chemistry/genetics | en |
dc.subject | Linkage Disequilibrium | en |
dc.subject | Molecular Sequence Data | en |
dc.subject | Phylogeny | en |
dc.subject | Polymorphism, Genetic | en |
dc.subject | Protein Structure, Tertiary | en |
dc.subject | Receptors, KIR3DL1/chemistry/*genetics | en |
dc.subject | Receptors, KIR3DS1/chemistry/*genetics | en |
dc.subject | Sequence Homology, Amino Acid | en |
dc.subject | Selection (Genetics) | - |
dc.title | Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박명희 | - |
dc.identifier.doi | 10.1038/ng2111 | - |
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