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Apical membrane antigen-1 (AMA-1) gene sequences of re-emerging Plasmodium vivax in South Korea

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Authors
Han, Eun-Taek; Park, Jae-Hwan; Shin, Eun-Hee; Choi, Min-Ho; Oh, Myoung-Don; Chai, Jong-Yil
Issue Date
2002-09-28
Publisher
대한기생충학회 = Korean Society of Parasitology
Citation
Korean J Parasitol 40: 157-162
Keywords
Amino Acid Sequence*Antigens, ProtozoanBase SequenceGenotypeMalaria, Vivax/*geneticsMembrane Proteins/chemistry/*geneticsMolecular Sequence DataPolymorphism, GeneticProtozoan Proteins/chemistry/*genetics
Abstract
Plasmodium vivax malaria re-emerged in South Korea in 1993, and epidemics continue since then. We examined genetic variation in the region encompassing the apical membrane antigen-1 (PvAMA-1) of the parasites by DNA sequencing of the 22 re-emerging P. vivax isolates. The genotype of the PvAMA-1, which was based on sequence data previously reported for the polymorphic regions, showed that two haplotypes were present at one polymorphic site. Compared with reported data, the two types, SKOR type I and type II, were similar to Chinese CH-10A and CH-05A isolates, respectively. Thus, the present study showed that two genotypes of AMA-1 genes coexist in the re-emerging Korean P. vivax.
ISSN
0023-4001 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12325446

https://hdl.handle.net/10371/12127
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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