S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
Apical membrane antigen-1 (AMA-1) gene sequences of re-emerging Plasmodium vivax in South Korea
- Issue Date
- 대한기생충학회 = Korean Society of Parasitology
- Korean J Parasitol 40: 157-162
- Amino Acid Sequence ; Base Sequence ; Genotype ; Malaria, Vivax/*genetics ; Membrane Proteins/chemistry/*genetics ; Molecular Sequence Data ; Polymorphism, Genetic ; Protozoan Proteins/chemistry/*genetics ; Antigens, Protozoan
- Plasmodium vivax malaria re-emerged in South Korea in 1993, and epidemics continue since then. We examined genetic variation in the region encompassing the apical membrane antigen-1 (PvAMA-1) of the parasites by DNA sequencing of the 22 re-emerging P. vivax isolates. The genotype of the PvAMA-1, which was based on sequence data previously reported for the polymorphic regions, showed that two haplotypes were present at one polymorphic site. Compared with reported data, the two types, SKOR type I and type II, were similar to Chinese CH-10A and CH-05A isolates, respectively. Thus, the present study showed that two genotypes of AMA-1 genes coexist in the re-emerging Korean P. vivax.
- 0023-4001 (Print)