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PLZF+ innate T cells support TGF-b-dependent generation of activated/memory-like regulatory T cells : PLZF-양성 선천면역 T 세포가 TGF-β 의존적인 활성화된 조절 T 세포 발달에 미치는 영향
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- Authors
- Advisor
- 정경천
- Major
- 의과대학 의학과
- Issue Date
- 2015-02
- Publisher
- 서울대학교 대학원
- Keywords
- regulatory T cells ; asthma ; T-T interaction
- Description
- 학위논문 (박사)-- 서울대학교 대학원 : 의학과, 2015. 2. 정경천.
- Abstract
- PLZF-expressing NKT cells and T-T CD4 T cells are unique subsets of
innate T cells. Both of them are selected via thymocyte-thymocyte (T-T)
interaction and simultaneously produce IL-4 and IFN-gama. Recently, it
was reported that these PLZF+ cells contributed to the generation of
effector/memory-like CD4 and CD8 T cells in the thymus. Based on
these previous findings, we investigated the possible role of PLZF+
innate T cells in the development and function of CD4+ Foxp+
regulatory T cells in CIITATgPIV-/- mice. In contrast to the counterparts
in wild type, Foxp3+ regulatory T cells in these mice exhibited
effector/memory-like phenotype: up-regulation of surface molecules
associated with regulatory functions (CD39 and CD73) and migrations
(CCR4), and efficiently suppressed ovalbumin-induced allergic airway
inflammation. During the course of intrathymic development, IL-4
produced by thymic PLZF+ T cells cooperated with TGF-beta for the
acquisition of effector/memory phenotype of regulatory T cells. This is
also the case in BALB/c mice where PLZF+ iNKT cells were the main
source of IL-4. Thus, PLZF+ innate T cells modulate the thymic
development of regulatory T cells as well as effector T cells.
- Language
- English
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