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PLZF+ innate T cells support TGF-b-dependent generation of activated/memory-like regulatory T cells
PLZF-양성 선천면역 T 세포가 TGF-β 의존적인 활성화된 조절 T 세포 발달에 미치는 영향

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Authors
강병현
Advisor
정경천
Major
의과대학 의학과
Issue Date
2015-02
Publisher
서울대학교 대학원
Keywords
regulatory T cellsasthmaT-T interaction
Description
학위논문 (박사)-- 서울대학교 대학원 : 의학과, 2015. 2. 정경천.
Abstract
PLZF-expressing NKT cells and T-T CD4 T cells are unique subsets of
innate T cells. Both of them are selected via thymocyte-thymocyte (T-T)
interaction and simultaneously produce IL-4 and IFN-gama. Recently, it
was reported that these PLZF+ cells contributed to the generation of
effector/memory-like CD4 and CD8 T cells in the thymus. Based on
these previous findings, we investigated the possible role of PLZF+
innate T cells in the development and function of CD4+ Foxp+
regulatory T cells in CIITATgPIV-/- mice. In contrast to the counterparts
in wild type, Foxp3+ regulatory T cells in these mice exhibited
effector/memory-like phenotype: up-regulation of surface molecules
associated with regulatory functions (CD39 and CD73) and migrations
(CCR4), and efficiently suppressed ovalbumin-induced allergic airway
inflammation. During the course of intrathymic development, IL-4
produced by thymic PLZF+ T cells cooperated with TGF-beta for the
acquisition of effector/memory phenotype of regulatory T cells. This is
also the case in BALB/c mice where PLZF+ iNKT cells were the main
source of IL-4. Thus, PLZF+ innate T cells modulate the thymic
development of regulatory T cells as well as effector T cells.
Language
English
URI
https://hdl.handle.net/10371/122045
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Theses (Ph.D. / Sc.D._의학과)
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