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Evaluation of Antiangiogenic Effect Using Arterial Spin Labeling Perfusion MR Imaging in Rat Glioblastoma Model Treated with Bevacizumab

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Authors
윤태진
Advisor
한문희
Major
의과대학 의학과
Issue Date
2016-02
Publisher
서울대학교 대학원
Keywords
GlioblastomaAntiangiogenic effectBevacizumabDynamic susceptibility contrastArterial spin labeling
Description
학위논문 (박사)-- 서울대학교 대학원 : 의과대학 의학과 , 2016. 2. 한문희.
Abstract
Background and Purpose– I evaluated the antiangiogenic effect of bevacizumab in a rat glioblastoma (GBM) model based on arterial spin labeling (ASL) perfusion MR imaging compared to dynamic susceptibility contrast (DSC) perfusion MR imaging with histopathology.
Materials and Methods– The protocol was approved by the institutional animal care and use committee. DSC and ASL perfusion MR imaging were performed using a 9.4 T MR scanner in nude rats with GBM. Rats were randomly assigned in the following three groups: control, 3-days treatment, and 10-days treatment. One-way analysis of variances was used to compare perfusion parameters (e.g. normalized cerebral blood volume [nCBV] from DSC MR imaging, and normalized cerebral blood flow [nCBF] based on DSC MR imaging and ASL MR imaging) with microvessel area (MVA) on histology Pearsons correlations between perfusion parameters and MVA were determined.
Results– MVA showed the consistent decrease with significant differences for the control, 3-days treatment, and 10-days treatment (P < 0.001). Consistent decreases with significant differences were also revealed in all perfusion parameters (P < 0.05 for all). In addition, nCBV and nCBF from DSC, and nCBF from ASL strongly correlated with MVA (R2 = 0.830, 0.755, and 0.739, respectively, P < 0.001 for all).
Conclusions– nCBF based on ASL has the potential to be used to evaluate the effect of antiangiogenic therapy on GBMs treated with bevacizumab with strong correlation with MVA.
Language
English
URI
https://hdl.handle.net/10371/122125
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Theses (Ph.D. / Sc.D._의학과)
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