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Efficacy of A Mouse Anti-human ICAM-1 Monoclonal Antibody, MD-3, for Kidney Transplantation in Rhesus Monkeys
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 하종원 | - |
dc.contributor.author | 민상일 | - |
dc.date.accessioned | 2017-07-14T01:34:58Z | - |
dc.date.available | 2017-07-14T01:34:58Z | - |
dc.date.issued | 2016-02 | - |
dc.identifier.other | 000000133544 | - |
dc.identifier.uri | https://hdl.handle.net/10371/122126 | - |
dc.description | 학위논문 (박사)-- 서울대학교 대학원 : 의과대학 의학과 외과학전공, 2016. 2. 하종원. | - |
dc.description.abstract | Introduction: The MD-3 is a newly developed chimeric anti-human intracellular adhesion molecule 1 (ICAM-1) monoclonal antibody (mAb). The effects of this monoclonal antibody in solid organ transplantation have not been elucidated.
Methods: Five rhesus monkey renal allograft recipients treated with MD-3 induction and one recipient without MD-3 treatment were studied for the incidence of acute rejection and donor-specific antibody development. Cellular immune response was tested with ELISPOT assay. Development of anti-drug antibody was also tested. Maintenance immunosuppression included anti-CD154 mAb (hu5C8), mycophenolate mofetil and corticosteroid. Results: No recipient monkey developed acute rejection as long as 8 months after transplantation. Donor-specific antibody was not developed in monkeys treated with MD-3. A monkey without MD-3 induction started to produce donor-specific antibody 3 weeks after cessation of anti-CD154mAb and persisted. No anti-drug antibody was detected during the study period. Conclusions: MD-3 can be a highly promising agent for clinical use in human allotransplantation and MD-3 treatment can allow optimization of kidney transplant outcome. Further studies for refining dosages and dosing schedule of MD-3 in kidney transplantation are required. | - |
dc.description.tableofcontents | Introduction 1
Materials and Methods 4 Results 12 Discussion 28 References 32 Abstract in Korean 37 | - |
dc.format | application/pdf | - |
dc.format.extent | 3216814 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Primate models | - |
dc.subject | MD-3 | - |
dc.subject | Renal transplantation | - |
dc.subject | Acute rejection | - |
dc.subject | Donor-specific antibody | - |
dc.subject.ddc | 610 | - |
dc.title | Efficacy of A Mouse Anti-human ICAM-1 Monoclonal Antibody, MD-3, for Kidney Transplantation in Rhesus Monkeys | - |
dc.type | Thesis | - |
dc.description.degree | Doctor | - |
dc.citation.pages | 44 | - |
dc.contributor.affiliation | 의과대학 의학과 | - |
dc.date.awarded | 2016-02 | - |
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