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Post-ischemic administration of pravastatin reduces neuronal injury by inhibiting Bax protein expression after transient forebrain ischemia in rats : 백서의 일과성 전뇌허혈 모델에서 허혈 후 프라바스타틴 투여로 인한 Bax 단백질 발현 억제에 의한 신경 세포 손상 감소
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 전영태 | - |
dc.contributor.author | 정유선 | - |
dc.date.accessioned | 2017-07-14T01:36:06Z | - |
dc.date.available | 2017-07-14T01:36:06Z | - |
dc.date.issued | 2016-08 | - |
dc.identifier.other | 000000135946 | - |
dc.identifier.uri | https://hdl.handle.net/10371/122145 | - |
dc.description | 학위논문 (박사)-- 서울대학교 대학원 : 의학과, 2016. 8. 전영태. | - |
dc.description.abstract | Introduction: This study investigated the neuroprotective effect of pravastatin administration after forebrain ischemia in rats.
Materials and Methods: Forebrain ischemia was induced by bilateral common carotid artery occlusion and systemic hypotension for 8 min. Pravastatin at 1 mg/kg (pravastatin group, n = 10), or an identical volume of normal saline (control group, n = 10), was injected 10 min, and 1-4 days after reperfusion. Arterial blood gas was analyzed 10 min before ischemia onset and 10 min after ischemia completion. Viable and apoptotic neuronal cells were evaluated 7 days after ischemia by hematoxylin and eosin (H&E) staining and terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuracil triphosphate biotin in situ nick-end labeling (TUNEL) staining of the hippocampal Cornu Ammonis area (CA1). Expression of Bcl-2 and Bax proteins was quantified by Western blot analysis. Results: The proportion of viable neuronal cells after ischemia was greater in the pravastatin vs. control group (p < 0.01), with greater expression of apoptotic cells in the control vs. pravastatin group (p < 0.05). Bax protein expression was significantly decreased in the pravastatin group (p < 0.05), whereas Bcl-2 expression was increased, but not significantly (p > 0.05). Conclusions: Our findings suggest that pravastatin administration after forebrain ischemia confers neuroprotection in rats by inhibiting Bax protein expression. | - |
dc.description.tableofcontents | Introduction 1
Materials and Methods 3 Results 8 Discussion 10 Conclusions 15 References 16 Korean Abstract 21 | - |
dc.format | application/pdf | - |
dc.format.extent | 551584 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | apoptosis | - |
dc.subject | Bax protein | - |
dc.subject | brain ischemia | - |
dc.subject | pravastatin | - |
dc.subject.ddc | 610 | - |
dc.title | Post-ischemic administration of pravastatin reduces neuronal injury by inhibiting Bax protein expression after transient forebrain ischemia in rats | - |
dc.title.alternative | 백서의 일과성 전뇌허혈 모델에서 허혈 후 프라바스타틴 투여로 인한 Bax 단백질 발현 억제에 의한 신경 세포 손상 감소 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | Yoo Sun Jung | - |
dc.description.degree | Doctor | - |
dc.citation.pages | v, 31 | - |
dc.contributor.affiliation | 의과대학 의학과 | - |
dc.date.awarded | 2016-08 | - |
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