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Analysis of hemodynamic force acting on coronary plaque and its relationship with lesion geometry : 관상동맥 경화반에 작용하는 혈역학적 외력과 병변의 형태적 특징에 따른 혈역학적 외력의 분포에 대한 분석

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의과대학 의학과
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서울대학교 대학원
coronary artery diseaseaxial plaque stresswall shear stresspressurecoronary plaquecomputational fluid dynamicscoronary computed tomography angiography.
학위논문 (박사)-- 서울대학교 대학원 : 의학과, 2016. 7. 손대원.
Background: Coronary plaque rupture occurs when plaque stress exceeds plaque strength. We performed this study to characterize the hemodynamic force acting on plaque and to investigate its relationship with lesion geometry.
Methods: Computational fluid dynamics was applied to 114 lesions (81 patients) from coronary computed tomographic (CT) angiography. The axial plaque stress (APS) was computed by extracting the axial component of hemodynamic stress acting on stenotic lesions and the axial lesion asymmetry was assessed by the luminal radius change over length (radius gradient, RG). Lesions were divided into upstream-dominant (upstream RG > downstream RG) and downstream-dominant lesions (upstream RG < downstream RG) according to the RG.
Results: 33 lesions (28.9%) showed net retrograde axial plaque force. Upstream APS linearly increased as lesion severity increased whereas downstream APS exhibited a concave function for lesion severity. There was a negative correlation (r=-0.274, p=0.003) between APS and lesion length. The pressure gradient, CT-derived fractional flow reserve (FFRCT), and wall shear stress (WSS) were consistently higher in upstream segments, regardless of the lesion asymmetry. However, APS was higher in the upstream segment of upstream-dominant lesions (11371.96 ± 5575.14 vs. 6878.14 ± 4319.51 dyne/cm2, p<0.001), and in the downstream segment of downstream-dominant lesions (7681.12 ± 4556.99 vs. 11990.55 ± 5556.64 dyne/cm2, p<0.001). Although there were no differences in FFRCT, % diameter stenosis and WSS pattern, the distribution of APS was different between upstream- and downstream-dominant lesions.
Conclusion: APS uniquely characterizes the stenotic segment and has a strong relationship with lesion geometry. Clinical application of these hemodynamic and geometric indices may be helpful to assess the future risk of plaque rupture and to determine treatment strategy for patients with coronary artery disease.
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