Helicobacter pylori eradication down-regulates cellular inhibitor of apoptosis protein 2 in gastric carcinogenesis
위암에서 헬리코박터 파일로리 제균치료에 의한 cIAP2 발현의 하향 조절

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dc.description학위논문 (박사)-- 서울대학교 대학원 : 의학과 내과학 전공, 2016. 8. 정현채.-
dc.description.abstractBackground: To evaluate the expression of cellular inhibitor of apoptosis protein 2 (cIAP2) during gastric carcinogenesis after Helicobacter pylori (HP) infection and after HP eradication
Methods: We divided non-cancer patients into 4 groups according to the status of HP infection and atrophic gastritis (AG)/intestinal metaplasia (IM)
dc.description.abstractwe compared cIAP2 mRNA expression among these 4 groups and patients with HP-positive early gastric cancer (EGC) by real-time PCR. We evaluated the expression of cIAP2 mRNA/protein by real-time PCR/immunohistochemistry, and the degree of apoptosis by TUNEL assay before and 12 months after endoscopic submucosal dissection (ESD) in HP-positive EGC patients irrespective of whether they received eradication therapy.
Results: The expression of cIAP2 mRNA was significantly higher in groups with HP(+) and AG/IM(+) and HP-positive EGC than in the control, HP(+) and AG/IM(-) groups (p < 0.005). In the HP eradication group, the expression of cIAP2 mRNA/protein significantly decreased (p = 0.006) and apoptosis increased at the 12-month follow-up after ESD. In the HP non-eradication group, the aforementioned changes were not found at the same follow-up period.
Conclusion: The expression of cIAP2 increased during gastric carcinogenesis after HP infection
dc.description.abstractHP eradication in the patients who underwent ESD for EGC reversed the over-expression of cIAP2 and suppressed cell apoptosis.-
dc.description.tableofcontentsIntroduction 1

Materials and Methods 3

Results 12

Discussion 19

References 23

국문 초록 28
dc.format.extent718401 bytes-
dc.publisher서울대학교 대학원-
dc.subjectHelicobacter pylori-
dc.subjectellular inhibitor of apoptosis protein 2-
dc.subjectgastric carcinogenesis-
dc.titleHelicobacter pylori eradication down-regulates cellular inhibitor of apoptosis protein 2 in gastric carcinogenesis-
dc.title.alternative위암에서 헬리코박터 파일로리 제균치료에 의한 cIAP2 발현의 하향 조절-
dc.contributor.affiliation의과대학 의학과-
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Theses (Ph.D. / Sc.D._의학과)
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