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Helicobacter pylori eradication down-regulates cellular inhibitor of apoptosis protein 2 in gastric carcinogenesis : 위암에서 헬리코박터 파일로리 제균치료에 의한 cIAP2 발현의 하향 조절
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 정현채 | - |
dc.contributor.author | 윤혁 | - |
dc.date.accessioned | 2017-07-14T01:37:37Z | - |
dc.date.available | 2017-07-14T01:37:37Z | - |
dc.date.issued | 2016-08 | - |
dc.identifier.other | 000000136788 | - |
dc.identifier.uri | https://hdl.handle.net/10371/122174 | - |
dc.description | 학위논문 (박사)-- 서울대학교 대학원 : 의학과 내과학 전공, 2016. 8. 정현채. | - |
dc.description.abstract | Background: To evaluate the expression of cellular inhibitor of apoptosis protein 2 (cIAP2) during gastric carcinogenesis after Helicobacter pylori (HP) infection and after HP eradication
Methods: We divided non-cancer patients into 4 groups according to the status of HP infection and atrophic gastritis (AG)/intestinal metaplasia (IM) | - |
dc.description.abstract | we compared cIAP2 mRNA expression among these 4 groups and patients with HP-positive early gastric cancer (EGC) by real-time PCR. We evaluated the expression of cIAP2 mRNA/protein by real-time PCR/immunohistochemistry, and the degree of apoptosis by TUNEL assay before and 12 months after endoscopic submucosal dissection (ESD) in HP-positive EGC patients irrespective of whether they received eradication therapy.
Results: The expression of cIAP2 mRNA was significantly higher in groups with HP(+) and AG/IM(+) and HP-positive EGC than in the control, HP(+) and AG/IM(-) groups (p < 0.005). In the HP eradication group, the expression of cIAP2 mRNA/protein significantly decreased (p = 0.006) and apoptosis increased at the 12-month follow-up after ESD. In the HP non-eradication group, the aforementioned changes were not found at the same follow-up period. Conclusion: The expression of cIAP2 increased during gastric carcinogenesis after HP infection | - |
dc.description.abstract | HP eradication in the patients who underwent ESD for EGC reversed the over-expression of cIAP2 and suppressed cell apoptosis. | - |
dc.description.tableofcontents | Introduction 1
Materials and Methods 3 Results 12 Discussion 19 References 23 국문 초록 28 | - |
dc.format | application/pdf | - |
dc.format.extent | 718401 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Helicobacter pylori | - |
dc.subject | ellular inhibitor of apoptosis protein 2 | - |
dc.subject | gastric carcinogenesis | - |
dc.subject.ddc | 610 | - |
dc.title | Helicobacter pylori eradication down-regulates cellular inhibitor of apoptosis protein 2 in gastric carcinogenesis | - |
dc.title.alternative | 위암에서 헬리코박터 파일로리 제균치료에 의한 cIAP2 발현의 하향 조절 | - |
dc.type | Thesis | - |
dc.description.degree | Doctor | - |
dc.citation.pages | 29 | - |
dc.contributor.affiliation | 의과대학 의학과 | - |
dc.date.awarded | 2016-08 | - |
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