만성폐쇄성폐질환 환자에서 혈장 기질금속단백질분해효소 농도와 폐기능, 폐기종 정도의 관련성에 대한 연구

Abstract

Objective: Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation in the airway and the lung parenchyma. A protease-antiprotease imbalance has been suggested as a possible pathogenic mechanism for COPD. The relationship between matrix metalloproteinase (MMP) levels and COPD severity was evaluated. Methods: Plasma levels of MMP-1, MMP-8, MMP-9, and MMP-12 were measured in 57 COPD patients and 36 normal controls. The relationship between MMP levels and lung function, quality of life, emphysema index, bronchial wall thickness, and pulmonary artery (PA)/ascending aorta (A) diameter ratio were examined using general linear regression analyses. Results: There were significant associations of MMP-1 with bronchodilator reversibility, MMP-8 and MMP-9 with lung function. Additionally, MMP-1, MMP-8, and MMP-9 levels were correlated with the emphysema index, independent of lung function. However, MMP-12 was not associated with lung function or emphysema severity. Associations between MMP levels and bronchial wall thickness, PA/A ratio, and quality of life were not statistically significant. Conclusion: Plasma levels of MMP-1, MMP-8, and MMP-9 are associated with COPD severity and can help to better understand pathogenesis of COPD.