A 2-Axis Robotic Mirror Therapy System to Enhance Proprioception and Functional Recovery of Hemiplegic Arms in Patients with Stroke
뇌졸중 환자에서 고유감각 및 편마비측 상지 기능 회복 촉진을 위한 2축 거울상 로봇 치료 시스템

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dc.description학위논문 (박사)-- 서울대학교 대학원 : 의학과 의공학 전공, 2016. 8. 김성완.-
dc.description.abstractIntroduction: Mirror therapy has been performed as an effective occupational therapy in a clinical setting for functional recovery of a hemiplegic arm after stroke. It is conducted by eliciting a visual illusion through the use of a mirror as if the hemiplegic arm is moving in real-time while moving the healthy arm. It can facilitate brain neuroplasticity through activation of the sensorimotor cortex. However, conventional mirror therapy has a critical limitation in that the hemiplegic arm is not actually moving.
Methods: We developed a real-time 2-axis mirror robot system as a simple add-on module for conventional mirror therapy using a closed feedback mechanism, which allows for real-time movement of the hemiplegic arm. This is the first attempt that combined a robot with a real mirror for facilitation of proprioception followed by motor recovery. We used three attitude and heading reference system sensors, two brushless DC motors for elbow and wrist joints, and exoskeletal frames.
Results: Motion synchronicity between the motors in the hemiplegic arm and the AHRS sensors in the healthy arm was validated. A study with six healthy subjects showed that robotic mirror therapy was safe and feasible. We further selected useful tasks for activities of daily living training through feedback from six rehabilitation doctors. Two chronic stroke patients showed improvement in the Fugl-Meyer assessment scale and elbow flexor spasticity, proprioception and hemispatial neglect after a 2-week application of the mirror robot system. The enhancement of proprioceptive input can be explained by the functional MRI results. The results revealed that both the lower part of the superior parietal lobule and the premotor cortex (PMC) were activated during the passive range of motion (ROM) exercise, whereas the PMC was mainly activated during the active ROM exercise.
Conclusions: Robotic mirror therapy could enhance proprioceptive stimulus to the sensory cortex, which is considered to be very important in neuroplasticity and functional recovery of hemiplegic arms. The mirror robot system presented in this study can be easily developed and utilized effectively to advance occupational therapy.
dc.description.tableofcontentsIntroduction 1

Materials and Methods 5
1) Mirror therapy tasks 5
2) Components of the mirror robot system 8
3) Clinical application of the mirror robot system 22
4) Functional magnetic resonance imaging analysis 26

Results 29
1) Validation of motion synchronicity between the motors and AHRS sensors 29
2) A clinical study for healthy subjects 31
3) Feedback from rehabilitation doctors 34
4) A case study for stroke patients 34

Discussion 45

Conclusions 51

References 53

Supplementary figure and tables 59

Abstract in Korean 64
dc.format.extent1924016 bytes-
dc.publisher서울대학교 대학원-
dc.subjectMirror therapy-
dc.subjectrehabilitation robot-
dc.titleA 2-Axis Robotic Mirror Therapy System to Enhance Proprioception and Functional Recovery of Hemiplegic Arms in Patients with Stroke-
dc.title.alternative뇌졸중 환자에서 고유감각 및 편마비측 상지 기능 회복 촉진을 위한 2축 거울상 로봇 치료 시스템-
dc.contributor.AlternativeAuthorJaewon Beom-
dc.contributor.affiliation의과대학 의학과-
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Theses (Ph.D. / Sc.D._의학과)
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