Browse

M-CSF from Cancer Cells Induces Fatty Acid Synthase and PPARβ/δ Activation in Tumor Myeloid Cells, Leading to Tumor Progression
암 세포의 대식세포 콜로니 자극인자를 통한 골수성 세포의 지방산합성효소 및 PPARβ/δ 핵수용체 활성화에 따른 종양 성장의 기전

DC Field Value Language
dc.contributor.advisor김효수-
dc.contributor.author박종한-
dc.date.accessioned2017-07-14T01:45:05Z-
dc.date.available2017-07-14T01:45:05Z-
dc.date.issued2016-02-
dc.identifier.other000000133015-
dc.identifier.urihttps://hdl.handle.net/10371/122307-
dc.description학위논문 (박사)-- 서울대학교 대학원 : 의과대학 의과학과, 2016. 2. 김효수.-
dc.description.abstractIntroduction: Tumor myeloid cells have a central role in tumor progression. However, the mechanism by which the myeloid cells sense the tumor microenvironment and activate their pro-tumoral function remains unclear.
Methods: Lewis lung carcinoma tumor model with PPARβ/δ-deficient bone marrow transplantation and adoptive transfer of wild-type macrophages were used to study the role of myeloid PPARβ/δ in tumor progression.
Results: PPARβ/δ is strongly expressed and activated in tumor myeloid cells. PPARβ/δ promotes tumor growth and angiogenesis by inducing pro-tumoral phenotype of myeloid cells. This pro-tumoral phenotype, represented as IL-10 expression, stimulates tumor cell invasion and angiogenesis apart from its well-known immune regulatory function.
Conclusions: The activation of PPARβ/δ in myeloid cell is dependent on increased fatty acid synthase expression, which is augmented by cancer cell derived cytokine, M-CSF.
-
dc.description.tableofcontentsGeneral Introduction 1

Chapter 1 PPARβ/δ in myeloid cells and tumor progression 3
Introduction 4
Material and Methods 5
Results 16
Discussion 31

Chapter 2 Dissecting the mechanism of PPARβ/δ mediated pro-tumoral myeloid cell activation 34
Introduction 35
Material and Methods 37
Results 45
Discussion 64

References 71

Abstract in Korean 82
-
dc.formatapplication/pdf-
dc.format.extent87012799 bytes-
dc.format.mediumapplication/pdf-
dc.language.isoen-
dc.publisher서울대학교 대학원-
dc.subjectTumor Microenvironment-
dc.subjectMyeloid Cells-
dc.subjectPPAR delta-
dc.subjectInterleukin-10-
dc.subjectFatty Acid Synthases-
dc.subject.ddc610-
dc.titleM-CSF from Cancer Cells Induces Fatty Acid Synthase and PPARβ/δ Activation in Tumor Myeloid Cells, Leading to Tumor Progression-
dc.title.alternative암 세포의 대식세포 콜로니 자극인자를 통한 골수성 세포의 지방산합성효소 및 PPARβ/δ 핵수용체 활성화에 따른 종양 성장의 기전-
dc.typeThesis-
dc.contributor.AlternativeAuthorJonghanne Park-
dc.description.degreeDoctor-
dc.citation.pagesv, 83-
dc.contributor.affiliation의과대학 의과학과-
dc.date.awarded2016-02-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biomedical Sciences (대학원 의과학과)Theses (Ph.D. / Sc.D._의과학과)
Files in This Item:
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse