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Identification of Tentonin 3, a Novel Mechanosensitive Channel and Its Role in Proprioception

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Authors
홍규상
Advisor
오우택
Major
융합과학기술대학원 분자의학 및 바이오제약학과
Issue Date
2016-08
Publisher
서울대학교 융합과학기술대학원
Keywords
Mechanosensation
Description
학위논문 (박사)-- 서울대학교 융합과학기술대학원 : 바이오제약학과, 2016. 8. 오우택.
Abstract
Touch sensation or proprioception requires the transduction of
mechanical stimuli into electrical signals by mechanoreceptors in the
periphery. These mechanoreceptors are equipped with various transducer
channels. Although Piezo1 and 2 are mechanically activated (MA) channels
with rapid inactivation, MA molecules with other inactivation kinetics have
not been identified. Here we report that heterologously expressed
Tentonin3 (TTN3)/TMEM150C is activated by mechanical stimuli with
distinctly slow inactivation kinetics. Genetic ablation of Ttn3/Tmem150c
markedly reduced slowly adapting neurons in dorsal-root ganglion neurons.
The mechanically-activated TTN3 currents were inhibited by knownblockers
of mechanosensitive ion channels. Moreover, TTN3 was localized
in muscle spindle afferents. Ttn3-deficient mice exhibited the loss of
coordinated
Language
English
URI
https://hdl.handle.net/10371/122413
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Theses (Ph.D. / Sc.D._분자의학 및 바이오제약학과)
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