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Identification of Tentonin 3, a Novel Mechanosensitive Channel and Its Role in Proprioception
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- Authors
- Advisor
- 오우택
- Major
- 융합과학기술대학원 분자의학 및 바이오제약학과
- Issue Date
- 2016-08
- Publisher
- 서울대학교 융합과학기술대학원
- Keywords
- Mechanosensation
- Description
- 학위논문 (박사)-- 서울대학교 융합과학기술대학원 : 바이오제약학과, 2016. 8. 오우택.
- Abstract
- Touch sensation or proprioception requires the transduction of
mechanical stimuli into electrical signals by mechanoreceptors in the
periphery. These mechanoreceptors are equipped with various transducer
channels. Although Piezo1 and 2 are mechanically activated (MA) channels
with rapid inactivation, MA molecules with other inactivation kinetics have
not been identified. Here we report that heterologously expressed
Tentonin3 (TTN3)/TMEM150C is activated by mechanical stimuli with
distinctly slow inactivation kinetics. Genetic ablation of Ttn3/Tmem150c
markedly reduced slowly adapting neurons in dorsal-root ganglion neurons.
The mechanically-activated TTN3 currents were inhibited by knownblockers
of mechanosensitive ion channels. Moreover, TTN3 was localized
in muscle spindle afferents. Ttn3-deficient mice exhibited the loss of
coordinated
- Language
- English
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