S-Space College of Engineering/Engineering Practice School (공과대학/대학원) Program in Bioengineering (협동과정-바이오엔지니어링전공) Theses (Master's Degree_협동과정-바이오엔지니어링전공)
Polymeric Tube-Shaped Devices with Controlled Geometry for Programmed Drug Delivery
- 공과대학 협동과정 바이오엔지니어링전공
- Issue Date
- 서울대학교 대학원
- Continuous drug release; Drug-Delivery tube; Polyethylene oxide; Programmed drug delivery; Pulsatile drug delivery
- 학위논문 (석사)-- 서울대학교 대학원 : 협동과정 바이오엔지니어링전공, 2012. 8. 최영빈.
- We developed a modular tube-shaped device as a proof of principle to enable programmed release of encapsulated molecules for controlled drug delivery. Each drug-delivery tube module was prepared by assembling two separate silicone tubes in series, one filled with a model compound (sodium fluorescein) and the other with a diffusional barrier material, polyethylene oxide (PEO). We varied the length of the PEO-filled tubes to control release from the drug-delivery tube devices. The onset times and periods of drug release increased with the length of the PEO tube in the drug-delivery tube device. To program drug release, therefore, we prepared devices with combinations of drug-delivery tube modules with PEO-filled tubes of different lengths. The combination of drug-delivery tubes with PEO-filled tubes each with very different lengths achieved pulsatile drug release, while a continuous drug release was realized by using a collection of PEO-filled tubes with small differences in length. We conclude that the modular combination of drug-delivery tubes, each composed of a diffusion-barrier tube of different length, demonstrates potential applications in programmed drug delivery.