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Nanoparticle coating on silane modified surface of magnesium for local drug delivery and controlled corrosion

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dc.contributor.advisor최영빈-
dc.contributor.author이원석-
dc.date.accessioned2017-07-14T02:23:11Z-
dc.date.available2017-07-14T02:23:11Z-
dc.date.issued2015-02-
dc.identifier.other000000025591-
dc.identifier.urihttps://hdl.handle.net/10371/122445-
dc.description학위논문 (석사)-- 서울대학교 대학원 : 협동과정 바이오엔지니어링전공, 2015. 2. 최영빈.-
dc.description.abstractIn this study, we proposed a potential method for the preparation of a magnesium (Mg)-based medical device for local drug delivery and controlled corrosion. A Mg surface was modified with 3-aminopropyltrimethoxy silane, and the resulting surface was then coated with drug loaded nanoparticles made of poly (lactic-co-glycolic acid) (PLGA) via electrophoretic deposition (EPD). The drug-loaded nanoparticles (i.e., Tr_NP) exhibited a size of 250 ± 67 nm and a negative zeta potential of -20.9 ± 2.75 mV. The drug was released from the nanoparticles in a sustained manner for 21 days, and this did not change after their coating on the silane-modified Mg. The silane-modified surface suppressed Mg corrosion. When immersed in phosphate buffered saline (PBS) at pH 7.4, the average rate of hydrogen gas generation was 0.41 - 0.45 ml/cm2/day, compared to 0.58 - 0.6 ml/cm2 /day from a bare Mg surface. This corrosion profile was not significantly changed after nanoparticle coating under the conditions employed in this work. The in vitro cell test revealed that the drug released from the coating was effective during the whole release period of 21 days, and both the silane-modified surface and carrier nanoparticles herein were not cytotoxic.-
dc.description.tableofcontentsContents
Abstract ……………………………………………i
Contents .…………………………………………iii
List of Figures ……………………………………v
List of Tables ……………………………………viii
Ⅰ. Introduction …………………………………1
1.1. Magnesium (Mg) materials and local drug delivery 1
1.2. Strategy .……………………………………2
Ⅱ. Materials and methods ……………………5
2.1. Materials ……………………………………5
2.2. Preparation of nanoparticles .……………5
2.3. Preparation of Mg samples ………………6
2.4. Characterization of nanoparticles………8
2.5. Evaluation of Mg samples ………………9
2.6. In vitro drug release study ………………9
2.7. In vitro corrosion test ……………………10
2.8. In vitro cell test ……………………………10
2.9. Statistical analysis………………………12

Ⅲ. Results ………………………………………14
3.1. Characterization of nanoparticles ……14
3.2. Characterization of coatings …………19
3.3. In vitro drug release profile ……………23
3.4. In vitro Mg corrosion property …………25
3.5. In vitro cell test .…………………………29
Ⅳ. Discussion …………………………………31
Ⅴ. Conclusion …………………………………34
Ⅵ. References …………………………………35
Ⅶ. Appendix ……………………………………41
국문초록……………………………………………42
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dc.formatapplication/pdf-
dc.format.extent1384251 bytes-
dc.format.mediumapplication/pdf-
dc.language.isoen-
dc.publisher서울대학교 대학원-
dc.subjectcoating-
dc.subjectcorrosion-
dc.subjectdrug delivery-
dc.subjectmagnesium-
dc.subjectnanoparticles-
dc.subjectsilane-
dc.subject.ddc660-
dc.titleNanoparticle coating on silane modified surface of magnesium for local drug delivery and controlled corrosion-
dc.typeThesis-
dc.description.degreeMaster-
dc.citation.pages44-
dc.contributor.affiliation공과대학 협동과정 바이오엔지니어링전공-
dc.date.awarded2015-02-
Appears in Collections:
College of Engineering/Engineering Practice School (공과대학/대학원)Program in Bioengineering (협동과정-바이오엔지니어링전공)Theses (Master's Degree_협동과정-바이오엔지니어링전공)
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