Publications
Detailed Information
Genomewide association study on the severity of periodontitis in Korean population: results from the Yangpyeong health cohort : 한국인의 치주질환에 대한 전장유전체연관분석
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 김현덕 | - |
dc.contributor.author | 신명섭 | - |
dc.date.accessioned | 2017-07-14T05:44:18Z | - |
dc.date.available | 2017-07-14T05:44:18Z | - |
dc.date.issued | 2016-02 | - |
dc.identifier.other | 000000132853 | - |
dc.identifier.uri | https://hdl.handle.net/10371/125105 | - |
dc.description | 학위논문 (박사)-- 서울대학교 대학원 : 치의과학과 예방치학전공, 2016. 2. 김현덕. | - |
dc.description.abstract | Objective: This study aims to locate the genes related to periodontitis through genome-wide association study (GWAS) in Korean population.
Methods: Total of 677 adults aged 44-88 years were recruited from the Yangpyeong cohort in Korea. The participants did not have self-reported metabolic diseases, cardiovascular diseases or cancer. Periodontitis was assessed using alveolar bone loss from a digital panoramic radiograph and classified into three groups: normal to mild, moderate and severe periodontitis. DNA from blood samples were genotyped using the Illumina Human 1M-duo Beadchip. Multivariable logistic regression analysis in PLINK was applied to examine the SNPs related to periodontitis after controlling for various confounders. Results: Associations of three SNPs suggested TENM2 (rs4242220) and LDLRAD4 (rs12969041, rs2027756) as putative risk genes of chronic periodontitis (p-values< 1 × 10-5). The odds ratio (95% confidence interval [CI]) of TENM2 was 0.53 (0.40-0.70) for moderate periodontitis and that of LDLRAD4 was 2.86 (1.92-4.27) for severe periodontitis. Two nonsynonymous SNPs of protein coding region and seven SNPs selected from previous reports showed nominal association. Conclusion: Our GWAS supports a previously reported gene of TENM2 and newly suggests LDLRAD4. These two genes role on lipid metabolism may play a part in the molecular etiology of periodontitis. | - |
dc.description.tableofcontents | 1. INTRODUCTION 1
2. METHODS 2 3. RESULTS 7 4. DISCUSSION 9 5. CONCLUSIONS 13 TABLE 14 FIGURE 16 REFERENCES 17 KOREAN ABSTRACT 20 | - |
dc.format | application/pdf | - |
dc.format.extent | 806609 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | GWAS | - |
dc.subject | epidemiology | - |
dc.subject | SNP | - |
dc.subject | Korean | - |
dc.subject.ddc | 617 | - |
dc.title | Genomewide association study on the severity of periodontitis in Korean population: results from the Yangpyeong health cohort | - |
dc.title.alternative | 한국인의 치주질환에 대한 전장유전체연관분석 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | Myung-Seop Shin | - |
dc.description.degree | Doctor | - |
dc.citation.pages | 21 | - |
dc.contributor.affiliation | 치의학대학원 치의과학과 | - |
dc.date.awarded | 2016-02 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.