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Hydrogel microcontainers with tunable physical properties prepared by polyionic complexation : 이온 복합체 형성을 통해 물리적 성질 조절이 가능한 수화젤 마이크로 수송체 구조에 관한 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 차국헌 | - |
dc.contributor.author | 이수지 | - |
dc.date.accessioned | 2017-07-17T08:42:38Z | - |
dc.date.available | 2017-07-17T08:42:38Z | - |
dc.date.issued | 2013-02 | - |
dc.identifier.other | 000000008183 | - |
dc.identifier.uri | https://hdl.handle.net/10371/127044 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 화학생물공학부, 2013. 2. 차국헌. | - |
dc.description.abstract | Synthesis of hydrogel hollow capsules provides the opportunity to extend the applications of gel materials as carriers. We report on biocompatible poly(vinylamine) (PVAm) hydrogel hollow microcontainers derived from well-defined precursor polymer, poly(N-vinylformamide) (PNVF). Herein, PNVF particles were synthesized via dispersion polymerization, varying either of crosslinking agent concentrations or steric stabilizer concentrations with the aim of probing the key factors that facilitate hollow structure. Uniform PVAm hydrogel capsules were consecutively prepared from PNVF, provided PNVF were attained in a sufficiently cross-linked structure.
Subsequently, taking advantage of protonated amine in PVAm at alkaline condition, we constructed PVAm-hyaluronic acid (HA) complexes with two descriptions of HA, possessing different molecular weight. We thus confirmed complex structures with NMR cryoporometry analysis that PVAm-short HA chain complexes (PVAm-SHA) contains denser shell structure than that of PVAm-long HA chain complex (PVAm-LHA). This, in turn, leads to the PVAm-SHA with higher stability against external stimuli, near-infrared (NIR) laser irradiation. For imparting light absorption in NIR region, we introduced gold nanorod (AuNR) to the PVAm-HA complexes. Consequently, PVAm-SHA exhibited improved durability and light stability when compared with PVAm-LHA during the local heating of AuNRs by NIR irradiation. In this study, we thus practically synthesized hydrogel hollow capsules in different size and also verified the structural change of polyion shell complexes by varying the chain length of HA, leading to enhancement of mechanical strength and light durability. As a consequence, the hollow PVAm-HA capsules developed in the present study can serve as promising microcontainers for therapeutic delivery systems. | - |
dc.description.tableofcontents | Modification of Network System 21
3.4.1 Influence of Hyaluronic Acid Molecular Weight on Complexation 21 3.4.2 Pore Size Distribution within Poly(vinylamine)-Hyaluronic Acid Complexes 26 3.4.3 Light Durability of Poly(vinylamine)-Hyaluronic Acid Complexes 28 Chapter 4. Conclusion 31 References 33 초 록 36 | - |
dc.description.tableofcontents | Contents
Chapter 1. Introduction 1 Chapter 2. Experimental 4 2.1 Materials 4 2.2 Synthesis of Poly(N-vinylformamide) Spherical Particles 4 2.2.1 Dispersion Polymerization of Poly(N-vinylformamide Spherical Particles | - |
dc.description.tableofcontents | Control of N,N-methylene bisacrylamide 5
2.2.2 Dispersion Polymerization of Poly(N-vinylformamide) Spherical Particles | - |
dc.description.tableofcontents | Control of Poly(2-ethyl-2-oxazoline) 5
2.3 Fabrication of Poly(vinylamine) Hydrogel Hollow Capsules 6 2.4 Preparation of Poly(vinylamine)- Hyaluronic Acid Polyion Complexes 6 2.5 Characterization 7 2.5.1 Confocal Laser Scanning Microscopy (CLSM) 7 2.5.2 Nuclear Magnetic Resonance (NMR) Cryoporometry7 2.5.3 Near-Infrared (NIR) Laser Irradiation 8 Chapter 3. Results and Discussion 11 3.1 Dispersion Polymerization of Poly(N-vinylformamide-co-N,N-methylenebisacrylamide) with Adjusting Synthetic Parameters 11 3.1.1 Control of Crosslinking Agent Concentration 11 3.1.2 Control of Steric Stabilizer Concentration 13 3.2 Poly(vinylamine) Hydrogel Hollow Capsules | - |
dc.description.tableofcontents | Effect of Crosslinking Agent 16
3.2.1 Control of N,N-methylenebisacrylamide Concentration16 3.3 Poly(vinylamine) Hydrogel Hollow Capsules | - |
dc.description.tableofcontents | Effect of Particle Size 19
3.4 Poly(vinylamine)-Hyaluronic Acid Complexation | - |
dc.format | application/pdf | - |
dc.format.extent | 1237599 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject.ddc | 660 | - |
dc.title | Hydrogel microcontainers with tunable physical properties prepared by polyionic complexation | - |
dc.title.alternative | 이온 복합체 형성을 통해 물리적 성질 조절이 가능한 수화젤 마이크로 수송체 구조에 관한 연구 | - |
dc.type | Thesis | - |
dc.description.degree | Master | - |
dc.citation.pages | 36 | - |
dc.contributor.affiliation | 공과대학 화학생물공학부 | - |
dc.date.awarded | 2013-02 | - |
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