The study on the oxidation of DNA-Silver nanodots and its application

Abstract

Fluorescence has been progressively adapted toward in vivo molecular imaging recently because of their high sensitivity and selectivity, which make it possible to detect target at single molecule level with a high temporal resolution, in optimized system. To achieve efficacy of fluorescence imaging, a proper fluorescence probe is essential. ssDNA encapsulated Ag NDs are most attractive emerging fluorophores, because of their excellent photophysical properties and reasonable biocompatibility. However accurate structures and synthetic mechanisms of DNA-Ag NDs are still not clear. Therefore analyzing the response of DNA-Ag NDs in the process of oxidation gives us better understanding of DNA-Ag NDs. We examined the oxidation process of NDs by using red emissive DNA-Ag ND molecules in the presence of various reactive oxygen species. In addition, with discovered oxidative properties, we have developed ratiometric luminescence probes and new form of imaging process.