Oxidative Stress Biomarkers among Residents measured 6 years after the Hebei Spirit Oil Spill
허베이스피리트호 유류유출사고 6년 후 피해지역 주민의 산화손상지표 농도

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dc.contributor.authorJung-Ah Kim-
dc.description학위논문 (석사)-- 서울대학교 보건대학원 : 환경보건학과 환경보건전공, 2016. 8. 최경호.-
dc.description.abstractIn December 2007, the Hebei Spirit oil spill accident occurred on the west coast of South Korea. Among the local residents, a dose-response relationship between the exposure to crude oil and urinary oxidative stress biomarkers was reported previously, 1.5 years after the oil spill. The aim of this study was to examine possible longer term effects associated with the exposure to oil spill among the residents, six years after the oil spill, especially in terms of oxidative stress biomarkers.
The target subjects were recruited based on the location of their residence and were also classified by their history of clean-up activities following the oil spill. In the vicinity of the oil spill, i.e., within 20 km from the oil spill site, a total of 476 adults (grouped as Near), and from the area beyond 20 km away from the spill site, 152 adults were recruited (grouped as Far) in 2014, respectivey. The participating adults were measured for 8–hydroxy–2–deoxyguanosine (8–OHdG) and malondialdehyde (MDA) levels in their 12-hour urine samples as indicators of oxidative DNA damage and lipid peroxidation, respectively. The subjects were also asked to fill the questionnaire. Multivariate general linear model was used to statistical analysis by SAS package (GLM procedure).
The geometric means (geometric standard deviation) of the urinary oxidative stress biomarkers measured in the study population were 5.31 (1.78) μg/g creatinine and 2.15 (1.71) μmol/g creatinine for urinary 8–OHdG and MDA levels, respectively. Duration of clean–up activities and the distance of residence from the oil spill site, showed significant association with both 8–OHdG and MDA levels, even after adjusting for sex, age, income, and creatinine corrected cotinine levels.
Even 6 years after the oil spill, positive associations between oxidative stress biomarkers and oil exposure were evident. While the present observation should be confirmed in other situations and populations, the results of this study suggest that the consequences of oil pollution may last for years. Health implication of this observation deserves further investigation.
dc.description.tableofcontentsChapter 1. Introduction 1
1.1. Study Background 1
1.2. Purpose of Research 2

Chapter 2. Materials and Methods 3
2.1. Study Population 3
2.2. Questionnaire 5
2.3. Measuremnet of Urinary Biomarkers 5
2.4. Statistical Analysis 6

Chapter 3. Results 7
3.1. Population Characteristics 7
3.2. Oil Spill related Characteristics of Study Population 9
3.3. Levels of Urinary Oxidative Stress Biomarkers 11
3.4. Associations with Urinary Oxidative Stress Biomarkers 12

Chapter 4. Discussion 15

Chapter 5. Conclusion 19

Supplements 20

Bibliography 24

Abstract in Korean 27
dc.format.extent1211705 bytes-
dc.publisher서울대학교 보건대학원-
dc.subjectEnvironmental disaster-
dc.subjectOil exposure-
dc.subjectLong–term health effect-
dc.subjectOil spill-
dc.subjectOxidative stress-
dc.titleOxidative Stress Biomarkers among Residents measured 6 years after the Hebei Spirit Oil Spill-
dc.title.alternative허베이스피리트호 유류유출사고 6년 후 피해지역 주민의 산화손상지표 농도-
dc.contributor.affiliation보건대학원 환경보건학과-
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Graduate School of Public Health (보건대학원)Dept. of Environmental Health (환경보건학과)Theses (Master's Degree_환경보건학과)
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