심외막지방 측정을 통한 복부 내장지방과 골무기질량의 연관성 분석

Abstract

Despite the detrimental effects of abdominal visceral fat on many cardiovascular and metabolic diseases, the relationship between abdominal visceral obesity and osteoporosis remains controversial. In the present study, we investigated the association between bone mass and abdominal fat estimated by echocardiographic epicardial fat thickness, which is a surrogate measure of abdominal visceral fat, anthropometric data, and regional fat mass (FM) measured by dual energy x-ray absorptiometry (DXA). A total of 1198 subjects (525 men, 460 premenopausal women, and 213 postmenopausal women) were selected from the Healthy Twin Study, a nationwide Korean twin and family study. Epicardial fat thickness was measured on the free wall of the right ventricle at end-systole from the parasternal long axis views. Total FM, regional FM, lean mass (LM), and bone mineral content (BMC) were measured by DXA. We performed multiple linear regression analysis with two models to determine the association between abdominal visceral obesity and osteoporosis. Age and height were included as covariates in Model 1. Past medical history and behavioral factors were included in Model 2. Epicardial fat thickness was positively associated with BMC in all three subgroups (men, premenopausal women, and postmenopausal women) in Model 1 and in Model 2. Trunk FM, waist circumference, and waist-to-hip ratio were also positively correlated to BMC in all three subgroups. Together, these findings suggest that abdominal visceral fat has a positive effect on BMC in the Korean population.