S-Space Graduate School of Public Health (보건대학원) Dept. of Public Health (보건학과) Theses (Master's Degree_보건학과)
Genetic Influences on HPV infection status in Korean women
한국인 여성에서 인유두종바이러스 감염여부의 유전적 영향
- 보건대학원 보건학과
- Issue Date
- 서울대학교 보건대학원
- 학위논문 (석사)-- 서울대학교 보건대학원 : 보건학과 유전체역학 전공, 2016. 2. 성주헌.
- Human papilloma virus (HPV) infection is a sexually transmitted infection (STI) and is a well-established cause of uterine cervix cancer. Although previous studies have reported that hosts genetic polymorphism is associated with HPV infection, it is not well understood whether host susceptibility is a true risk factor. This study aimed to assess the overall genetic contribution to HPV infection status, the first event in the natural course of carcinogenic infection, in a twin-family cohort in Korea.
Between 2006 and 2009, cervical smears were obtained from Papanicolaou (Pap) tests of 912 women (mean age 48
142 monozygotic twin (MZ) pairs) from 260 families that were participants of the Healthy Twin Study. HPV infection was diagnosed using two different PCR amplifications of partial sequences of HPV.
To investigate the correlation between HPV infection status of HPV types and environment factors, we used Spearmans correlation analysis. The association with HPV infection status and several environment factors was analyzed using multiple regressions with mixed model. Genetic factor which has effects on HPV infection status by HPV types was analyzed by two methods
Intraclass Correlation Coefficients (ICC) and heritability. Heritability was calculated by variance component method.
According to results of this study, correlation between HPV infection status of HPV types and environment factors, which is an important indicator of HPV infection, was oral contraceptive use. Although several environment factors were not associated with HPV infection status, genetic factor has mild association with HPV infection status. Concordance to discordance ratio within pairs was highest among MZ (3 to 19). This could be confirmed by ICC analysis using tetrachoric correlation coefficient and heritability analysis. Genetic components were estimated by heritability that was 0.24-0.31 for overall HPV infection, and when analyses were performed by the viral type
0.51-0.54 for lower risk strains and not significant for high-risk strains.
Our findings suggest that HPV infection status is influenced by a hosts genetic factors, viral genotype as well.