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Impacts of shift work induced chronic circadian disruption and gender on plasma inflammatory cytokine levels
교대근무에 따른 만성적 생체주기의 변화 및 성별이 혈중 염증성 cytokine 농도에 미치는 영향

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Authors
김동희
Advisor
정진우
Major
치과대학 치의과학과
Issue Date
2013-02
Publisher
서울대학교 대학원
Keywords
shift workcircadian rhythmplasmacytokinesleepgender difference
Description
학위논문 (석사)-- 서울대학교 대학원 : 치의과학과(구강내과진단학전공), 2013. 2. 정진우.
Abstract
Shift work can lead to disruption of the circadian rhythm which results in an irregular sleep pattern and subsequent alteration of plasma cytokine levels. And little is known about gender differences in plasma cytokine levels. The aims of this study were to investigate the impacts of shift work induced chronic circadian disruption and gender on plasma inflammatory cytokine levels.
Fifty-one healthy adults were recruited and divided into three age-matched groups according to gender and shift work status
Group A- day time working men (39.7 ± 3.3 years), Group B- night shift working men (39.1 ± 4.5 years), and Group C- day time working women (35.3 ± 11.5 years). The Pittsburgh Sleep Quality Index (PSQI) was assessed of each subject and plasma concentrations of IL-1β, IL-6, IL-10, and TNF-α were measured.
Group B subjects reported higher PSQI scores than Group A and C subjects and PSQI score was significantly associated with shift work status (β=0.372, p<0.05). There were significant differences in plasma IL-1β, IL-6, IL-10, and TNF- α levels among the three groups with Group B showing the highest, and Group C showing the lowest values. Plasma IL-6 level was significantly associated with PSQI score (β=0.317, p<0.05) and plasma levels of IL-1β (β=0.436, p<0.05), IL-10 (β=0.572, p<0.05), and TNF-α (β=0.630, p<0.05) were significantly associated with gender.
These results suggest that shift work induced chronic circadian disruption can worsen sleep quality and poor sleep quality increases plasma IL-6 level. Men have higher plasma IL-1β, IL-10, and TNF-α levels compared to women.
Language
English
URI
https://hdl.handle.net/10371/131110
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dental Science(치의과학과)Theses (Master's Degree_치의과학과)
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