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Antifungal substances produced by Lactobacillus plantarum LBP-K10 : Lactobacillus plantarum LBPK10 에서 생성된 항진균 물질

DC Field Value Language
dc.contributor.advisor강사욱-
dc.contributor.author김형진-
dc.date.accessioned2017-07-19T09:05:33Z-
dc.date.available2017-07-19T09:05:33Z-
dc.date.issued2014-02-
dc.identifier.other000000016726-
dc.identifier.urihttps://hdl.handle.net/10371/131555-
dc.description학위논문 (석사)-- 서울대학교 대학원 : 생명과학부, 2014. 2. 강사욱.-
dc.description.abstractLactobacillus plantarum LBP-K10 was identified to be the most potent
antifungal strain from Korean traditional fermented vegetables. The culture
filtrate of this strain showed remarkable antifungal activity against Ganoderma
boninense. Five fractions from the culture filtrate were observed to have an
inhibitory effect against G. boninense, and electron ionization and chemical
ionization indicated that these compounds might be cyclic dipeptides. Of the
five active fractions, two fractions showed the most significant anti-
Ganoderma activity, and one of these fractions inhibited the growth of
Candida albicans. These compounds were identified to be cis-cyclo(L-Val-LPro)
and cis-cyclo(L-Phe-L-Pro), as confirmed by X-ray crystallography.		-
dc.description.tableofcontentsCONTENTS
ABSTRACT ..................................................................................................... i
CONTENTS .................................................................................................... ii
LIST OF FIGURES ...................................................................................... iii
LIST OF TABLES ........................................................................................ iv
CHAPTER I INTRODUCTION ....................................................................... 1
CHAPTER II MATERIALS AND METHODS ................................................4
1. Strains ................................................................................................... 5
2. Fractionation of antifungal substances ................................................. 5
3. Antifungal test ...................................................................................... 6
4. Mass Analysis ...................................................................................... 6
5. X-ray crystallography Analysis ............................................................ 6
CHAPTER III RESULTS ........................................................................... 8
1. Identification of isolates from kimchi .................................................... 9
2. Fractionation of culture filtrate ............................................................ 13
3. Antifungal activity of fractions of the culture filtrate .......................... 16
4. Structural determination of antifungal substances ............................... 18
CHAPTER IV DISCUSSION ......................................................................... 29
CHAPTER V REFERENCES ........................................................................ 33		-
dc.formatapplication/pdf-
dc.format.extent983503 bytes-
dc.format.mediumapplication/pdf-
dc.language.isoen-
dc.publisher서울대학교 대학원-
dc.subjectLactobacillus plantarum LBP-K10-
dc.subjectculture filtrate-
dc.subjectcis-cyclo(LVal- L-Pro)-
dc.subjectcis-cyclo(L-Phe-L-Pro)-
dc.subjectGanoderma boninense-
dc.subjectCandida albicans-
dc.subject.ddc570-
dc.titleAntifungal substances produced by Lactobacillus plantarum LBP-K10-
dc.title.alternativeLactobacillus plantarum LBPK10 에서 생성된 항진균 물질-
dc.typeThesis-
dc.description.degreeMaster-
dc.citation.pagesiv,37-
dc.contributor.affiliation자연과학대학 생명과학부-
dc.date.awarded2014-02-
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