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Decrease in KAI1/CD82 expression of mural cells in response to angiogenic stimulus
혈관신생 촉진 자극이 주피세포 발현 항혈관신생 인자인 KAI1/CD82의 발현에 미치는 영향에 관한 연구

DC Field Value Language
dc.contributor.advisor김효수-
dc.contributor.author남브니엘-
dc.date.accessioned2017-07-19T10:06:21Z-
dc.date.available2020-03-02T02:41:59Z-
dc.date.issued2017-02-
dc.identifier.other000000141352-
dc.identifier.urihttps://hdl.handle.net/10371/132278-
dc.description학위논문 (석사)-- 서울대학교 대학원 : 협동과정 줄기세포생물학 전공, 2017. 2. 김효수.-
dc.description.abstractRecent studies have highlighted the role of mural cells and tetraspanin molecules in angiogenesis. We and others [1] previously observed that mice that lack KAI1 (also known as CD82), a tetraspanin family member, display higher angiogenic capacity compared to their WT counterpart. Intriguingly, KAI1 was primarily expressed on mural (perivascular) cells in both humans and mice. We next asked if KAI1 expression changes in response to angiogenic stimuli. Angiogenic cytokines reversibly reduced mRNA level of KAI1 in mural cells through Src/PKC-DNMT3A-mediated DNA methylation of Kai1 promoter region. On the other hand, endothelial KAI1 expression showed no significant changes upon angiokine treatment. Furthermore, protein level of KAI1 also was rapidly lowered upon cytokine stimulation through endocytosis. Our study suggests perivascular KAI1 may act as a switch regulating the transition between vessel quiescence and angiogenesis.-
dc.description.tableofcontentsIntroduction 1
Results 3
Discussion 7
Figures 9
Materials and Methods 18
Supplementary Tables 22
References 25
요약 (국문초록) 27
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dc.formatapplication/pdf-
dc.format.extent1490431 bytes-
dc.format.mediumapplication/pdf-
dc.language.isoen-
dc.publisher서울대학교 대학원-
dc.subject혈관신생-
dc.subject혈관 내피세포-
dc.subject혈관 벽세포-
dc.subject테트라스파닌-
dc.subject카이-원-
dc.subjectDNA 메틸화-
dc.subject세포 내 섭취-
dc.subject.ddc610-
dc.titleDecrease in KAI1/CD82 expression of mural cells in response to angiogenic stimulus-
dc.title.alternative혈관신생 촉진 자극이 주피세포 발현 항혈관신생 인자인 KAI1/CD82의 발현에 미치는 영향에 관한 연구-
dc.typeThesis-
dc.description.degreeMaster-
dc.citation.pages28-
dc.contributor.affiliation의과대학 협동과정줄기세포생물학전공-
dc.date.awarded2017-02-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Program in Stem Cell Biology (협동과정-줄기세포생물학전공)Theses (Master's Degree_협동과정-줄기세포생물학전공)
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