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Body Mass Index in late teens and Spontaneous Abortion in the Health Examinees Study (HEXA) : 18에서 20세의 체질량지수와

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Authors

정선재

Advisor
강대희
Major
의과대학 협동과정 종양생물학전공
Issue Date
2013-08
Publisher
서울대학교 대학원
Keywords
pre-pregnant body mass indexspontaneous abortionmaternal underweightfetal death
Description
학위논문 (석사)-- 서울대학교 대학원 : 협동과정 종양생물학전공, 2013. 8. 강대희.
Abstract
Introduction: Spontaneous abortion affects approximately 21% of recognized pregnancies in Korea. Until recently, a preponderance of studies have focused on the increased risk of spontaneous abortion in obese populations, while research on reduced body mass index (BMI) and its risk for spontaneous abortion is relatively uncommon. As previous studies advocate for different effects of BMI in adverse health outcomes in Asians, the relationship between BMI and spontaneous abortion needs to be reevaluated in the Korean population. This study aims to examine the role of pre-pregnancy BMI as an independent risk factor for spontaneous abortion.

Methods: The eligible population was selected from the Health Examinee Study (HEXA) cohort, which is a component of the Korean Genome and Epidemiology Study (KoGES). We conducted analyses on 39,933 women who have been pregnant and gave birth to singletons only. Participants BMI at age 18 or 20 was calculated through information gathered by questionnaires with trained interviewers. Also, information on general lifestyle factors and reproductive factors was collected. BMI range was classified generally by BMI criteria of the World Health Organization, Regional Office for the Western Pacific Region (WHO-WPRO) for Asians, and further reclassification was done. Unconditional logistic regression was done to calculate odds ratios, ordinal logistic regression and test of heterogeneity was done to compare the strata difference.

Results: On association analysis, women who were classified as underweight (BMI<18.5kg/㎡) have an increased risk of 1.3 (95% C.I. 1.1-1.4), normal weight I (BMI ≥18.5 to <20.5kg/㎡) women 1.2 (95% C.I. 1.0-1.3), normal weight II (BMI ≥20.5 to <23kg/㎡) 1.1 (95% C.I. 1.0-1.2) and obese (≥25kg/㎡) group 1.2 (95% C.I 1.0-1.4) compared to overweight at risk (≥23 to <25kg/㎡) group. Also in comparing the number of spontaneous abortions, the obese group showed differences between women who had only one spontaneous abortion compared to women who had more than one. We found the influence of BMI on spontaneous abortion differed between those who had never smoked and smokers. For all ranges except for the reference range, the risk of spontaneous abortion doubled. (underweight 1.23 vs. 2.32, normal range I 1.12 vs. 2.00, normal range II 1.09 vs. 1.94 and Obese 1.20 vs. 2.02).
Conclusions: This analysis on a large population revealed a reverse J-shaped association between BMI and spontaneous abortion in Koreans, with a pattern broadly similar to that seen in previous studies.
Language
English
URI
https://hdl.handle.net/10371/132285
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College of Medicine/School of Medicine (의과대학/대학원)Program in Cancer Biology (협동과정-종양생물학전공)Theses (Master's Degree_협동과정-종양생물학전공)
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