S-Space College of Medicine/School of Medicine (의과대학/대학원) Program in Cancer Biology (협동과정-종양생물학전공) Theses (Master's Degree_협동과정-종양생물학전공)
The mechanism of cancer cell type-specific regulation of radiation-induced apoptosis by cAMP signaling
cAMP 신호전달계가 방사선조사에 의한 암세포사멸을 세포특이적으로
- 의과대학 협동과정 종양생물학전공
- Issue Date
- 서울대학교 대학원
- 학위논문 (석사)-- 서울대학교 대학원 : 협동과정 종양생물학전공, 2014. 8. 전용성.
- cAMP signaling regulates apoptosis of various cancer cells, but the effect was different depending on the cell types. We investigated the difference in the mechanism for cAMP signaling to regulate apoptosis. The activation of cAMP signaling by treatment with forskolin in H1299 ling cancer cells augmented radiation-induced apoptosis with an increase in Bax expression and a decrease in Bcl-xL. In contrast, treatment of HeLa uterine cervical cancer cells with forskolin inhibited radiation-induced apoptosis with an increase in Bcl-2, Bcl-xL, and XIAP. The activation of cAMP signaling increased XIAP mRNA expression in HeLa cells, but not in H1299 cells. It is concluded that cAMP signaling exhibits different effects on radiation-induced apoptosis by differential expression of apoptosis-regulating protein in different cancer cell lines.