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Pretreatment with epidermal growth factor promotes primary hair recovery in the chemotherapy-induced alopecia : 화학요법으로 유발된 탈모에서 표피성장인자 전처치에 의한 일차모발회복

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dc.contributor.advisor권오상-
dc.contributor.authorSeung Hwan Paik-
dc.date.accessioned2017-07-19T10:09:35Z-
dc.date.available2017-07-19T10:09:35Z-
dc.date.issued2013-02-
dc.identifier.other000000008507-
dc.identifier.urihttps://hdl.handle.net/10371/132347-
dc.description학위논문 (석사)-- 서울대학교 대학원 : 임상의과학과, 2013. 2. 권오상.-
dc.description.abstractEpidermal growth factor (EGF) is not only a potent cell growth stimulant but also has a catagen-inducing effect on hair follicles. Because chemotherapeutic agents primarily damage anagen hair follicles, it would be important to investigate whether catagen inducers have beneficial effects in the prevention of chemotherapy-induced alopecia (CIA). I pretreated hair follicles with a vehicle or EGF (50 g/ml or 100 g/ml) before treatment with a chemotherapeutic agent, and I observed the severity of hair follicle damage after chemotherapy and examined the recovery patterns after CIA by using the C57BL/6 mouse model of cyclophosphamide-induced alopecia. To validate the catagen-inducing property and damage response pathway after CIA, I evaluated the hair cycle score in histological sections and the number of TdT-mediated dUTP nick end labeling (TUNEL)-positive cells in the hair bulbs of control and EGF-treated mice. To follow gross changes as well as to assess the progression of CIA and the recovery pattern after CIA, photographs of the back skin of mice were captured and analyzed. I confirmed that topical EGF application induced a catagen-like stage in anagen hair follicles after depilation-
dc.description.abstractI found that catagen-like hairs induced by EGF were protected from chemotherapy-mediated damage. Moreover, my results showed that EGF treatment favored primary hair recovery via the dystrophic anagen pathway after CIA. Given that hair follicles subjected to less severe chemotherapeutic insult enter the dystrophic anagen pathway followed by primary recovery, rather than entering the dystrophic catagen pathway followed by secondary recovery, the results of this study suggest that catagen inducers could be useful as a new alopecia-protection strategy, especially in the context of CIA.-
dc.description.tableofcontentsChapter 1 Introduction
Chapter 2 Materials and Methods
2.1 Materials
2.2 Animals
2.3 Pretreatment with rhEGF and CYP injection
2.4 Photographic and histomorphometric analyses
2.5 Immunofluorescent staining
2.6 Statistical analysis
Chapter 3 Results
3.1 Topical application of EGF induces catagen-like effects in the C57BL/6 mouse model of CIA
3.2 Pretreatment with EGF decreased the chemotherapeutic damage to hair follicles and preferentially activated the dystrophic anagen pathway
3.3 Pretreatment with EGF favored primary hair recovery after CIA
Chapter 4 Discussion
References
Abstract
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dc.formatapplication/pdf-
dc.format.extent1195251 bytes-
dc.format.mediumapplication/pdf-
dc.language.isoen-
dc.publisher서울대학교 대학원-
dc.subjectEpidermal growth factor-
dc.subjectchemotherapy-induced alopecia-
dc.subjectprimary hair recovery-
dc.subjectdystrophic anagen pathway-
dc.subject.ddc610-
dc.titlePretreatment with epidermal growth factor promotes primary hair recovery in the chemotherapy-induced alopecia-
dc.title.alternative화학요법으로 유발된 탈모에서 표피성장인자 전처치에 의한 일차모발회복-
dc.typeThesis-
dc.contributor.AlternativeAuthor백승환-
dc.description.degreeMaster-
dc.citation.pagesiii, 24-
dc.contributor.affiliation의과대학 임상의과학과-
dc.date.awarded2013-02-
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