Publications

Detailed Information

Comparison of Diagnostic Efficacy and Safety between 22-gauge Aspiration and Biopsy Needles for EUS-guided Sampling of Pancreatic Solid Lesions : 췌장 고형병변의 진단을 위한 내시경 초음파 유도하 세침흡인술 및 생검술용 22게이지 바늘의 진단능력과 안전성 비교

DC Field Value Language
dc.contributor.advisor류지곤-
dc.contributor.author박진명-
dc.date.accessioned2017-07-19T10:11:02Z-
dc.date.available2017-07-19T10:11:02Z-
dc.date.issued2014-02-
dc.identifier.other000000016773-
dc.identifier.urihttps://hdl.handle.net/10371/132381-
dc.description학위논문 (석사)-- 서울대학교 대학원 : 임상의과학과, 2014. 2. 류지곤.-
dc.description.abstractIntroduction: The advantage of EUS-guided fine needle biopsy (EUS-FNB) over fine needle aspiration (EUS-FNA) is that it allows the acquisition of histologic core tissues. We conducted this study to compare diagnostic efficacy and safety of the new 22-gauge core biopsy needle to those of FNA needle for diagnosis of pancreatic solid lesions in the absence of on-site cytopathologists.
Methods: The Patients who underwent EUS-FNA or FNB between September 2011 and December 2012 were reviewed retrospectively. Among them we enrolled patients who underwent the procedure for diagnosis of pancreatic solid lesion using 22-gauge needle. Diagnostic efficacy and safety were compared between FNA and FNB group. In addition, we analyzed whether the diagnostic yields of EUS-FNA and FNB vary according to the final diagnosis.
Results: A total of 148 patients were enrolled (73 FNA and 75 FNB). Two groups showed comparable diagnosis achievement rates (75.3 vs 84.0%, P=0.19), and no severe complication occurred. There were 128 pancreatic cancer (86.5%), 12 neuroendocrine tumor (8.1%), 4 autoimmune pancreatitis (2.7%), and 3 idiopathic pancreatitis (2.0%). In pancreatic cancer patients 68 FNA and 60 FNB were performed. Sensitivities of FNA and FNB were 75.0% and 85.0%, and there was no statistically significant difference (P=0.19). The sensitivity of EUS-FNA was similar to that of EUS-FNB in transduodenal puncture (73.9 vs 70.6%, P=1.0). In contrast, the sensitivity of EUS-FNA tended to be lower than that of EUS-FNB in transgastric puncture (75.6 vs 90.7%, P=0.06). Specificities were 100% in both groups. A total of 12 neuroendocrine tumor (NET) patients were included (3 FNA and 9 FNB). All patients were diagnosed as NET except a patient in the FNB group. Ki-67 index was measured in 5 patients of the FNB group, and it provided crucial information for the management of patients. FNB was performed for 3 autoimmune pancreatitis (AIP) patients, and it enabled histologic diagnosis of AIP for one of them.
Conclusions: In the absence of on-site cytopathologists, EUS-FNB is comparable to FNA for the diagnosis of pancreatic cancer, however FNB might be preferred to FNA when transgastric puncture is performed. EUS-FNB can be helpful in the diagnosis and management of NET and AIP.
-
dc.description.tableofcontentsAbstract i
Contents iii
List of tables iv
List of figures v
List of abbreviations vi

Introduction 1
Materials and Methods 3
Results 6
Discussion 10
References 15
Tables 18
Figures 20
Abstract in Korean 21
-
dc.formatapplication/pdf-
dc.format.extent783062 bytes-
dc.format.mediumapplication/pdf-
dc.language.isoen-
dc.publisher서울대학교 대학원-
dc.subjectEndoscopic Ultrasound-Guided Fine Needle Aspiration-
dc.subjectBiopsy-
dc.subjectPancreas-
dc.subject.ddc610-
dc.titleComparison of Diagnostic Efficacy and Safety between 22-gauge Aspiration and Biopsy Needles for EUS-guided Sampling of Pancreatic Solid Lesions-
dc.title.alternative췌장 고형병변의 진단을 위한 내시경 초음파 유도하 세침흡인술 및 생검술용 22게이지 바늘의 진단능력과 안전성 비교-
dc.typeThesis-
dc.description.degreeMaster-
dc.citation.pagesvi, 23-
dc.contributor.affiliation의과대학 임상의과학과-
dc.date.awarded2014-02-
Appears in Collections:
Files in This Item:

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share