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Ifosfamide, methotrexate, etoposide, and prednisolone plus L=asparaginase as a first-time therapy in stage III/IV NK/T-cell lumphoma, nasal typr : III/IV기 NK/T 세포 림프종에서 ifosfamide, methotrexate, etoposide, prednisone 및 L-asparaginase 복합항암화학요법의 치료성적
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 허대석 | - |
dc.contributor.author | 김미소 | - |
dc.date.accessioned | 2017-07-19T10:11:30Z | - |
dc.date.available | 2017-07-19T10:11:30Z | - |
dc.date.issued | 2014-02 | - |
dc.identifier.other | 000000016966 | - |
dc.identifier.uri | https://hdl.handle.net/10371/132392 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 임상의과학과, 2014. 2. 허대석. | - |
dc.description.abstract | Introduction: The prognosis of patients with stage III/IV NK/T-cell lymphoma (NTCL) is extremely poor. Although L-asparaginase (L-asp) is effective for NTCL, its significance has not been clearly demonstrated. In addition, there are few studies comparing treatment outcomes in stage III/IV NTCL. This study evaluated the efficacy of L-asp-based chemotherapy and prognostic factors in stage III/IV NTCL.
Patients and Methods: Seventy patients with newly diagnosed stage III/IV NTCL were enrolled between January 2000 and February 2013. Patients received ifosfamide, etoposide, methotrexate, and prednisolone (IMEP) plus L-asp (N=22) or combination chemotherapy without L-asp (N=48) as a first-line treatment. Clinical prognostic factors, treatment outcomes, and prognostic scores were compared between the groups. Results: After a median follow-up period of 12.8 months (range, 1.1-186.6 months), median overall survival (OS) and progression-free survival (PFS) were 11.3 months and 5.6 months, respectively. Treatment outcomes were superior in patients treated with IMEP plus L-asp compared to those treated with chemotherapy without L-asp (overall response rate 90.0% vs. 34.8%, P < 0.001 | - |
dc.description.abstract | complete remission rate 65.0% vs. 21.7%, P = 0.001). The OS and PFS were significantly higher for the IMEP plus L-asp group compared with the chemotherapy without L-asp group. In a multivariate analysis, use of chemotherapy without L-asp was an independent predictor for reduced OS (hazards ratio (HR) = 2.18, 95% confidence interval (CI) 1.08-4.40 | - |
dc.description.abstract | P = 0.030) and PFS (HR = 2.29, 95% CI 1.22-4.29 | - |
dc.description.abstract | P = 0.010).
Conclusions: IMEP plus L-asp is active against stage III/IV NTCL, and it is an independent predictor for improved survival. | - |
dc.description.tableofcontents | Introduction 1
Patients and Methods 3 Results 7 Discussion 18 References 23 Abstract in Korean 27 | - |
dc.format | application/pdf | - |
dc.format.extent | 457198 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | ifosfamide | - |
dc.subject | methotrexate | - |
dc.subject | etoposide | - |
dc.subject | prednisolone | - |
dc.subject | L-asparaginase | - |
dc.subject | NK/T세포 림프종 | - |
dc.subject.ddc | 610 | - |
dc.title | Ifosfamide, methotrexate, etoposide, and prednisolone plus L=asparaginase as a first-time therapy in stage III/IV NK/T-cell lumphoma, nasal typr | - |
dc.title.alternative | III/IV기 NK/T 세포 림프종에서 ifosfamide, methotrexate, etoposide, prednisone 및 L-asparaginase 복합항암화학요법의 치료성적 | - |
dc.type | Thesis | - |
dc.description.degree | Master | - |
dc.citation.pages | v, 28 | - |
dc.contributor.affiliation | 의과대학 임상의과학과 | - |
dc.date.awarded | 2014-02 | - |
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