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Effect of inhalers on the development of hemoptysis in patients with non-cystic fibrosis bronchiectasis : 기관지확장증 환자에서 흡입기 사용이 객혈 발생에 미치는 영향에 관한 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 임재준 | - |
dc.contributor.author | 이정규 | - |
dc.date.accessioned | 2017-07-19T10:11:48Z | - |
dc.date.available | 2017-07-19T10:11:48Z | - |
dc.date.issued | 2014-02 | - |
dc.identifier.other | 000000017044 | - |
dc.identifier.uri | https://hdl.handle.net/10371/132397 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 임상의과학과, 2014. 2. 임재준. | - |
dc.description.abstract | Introduction: The association of inhaler use with hemoptysis has rarely been reported in patients with non-cystic fibrosis (CF) bronchiectasis. We aimed to elucidate the effect of inhaler use on the development of hemoptysis in patients with non-CF bronchiectasis.
Methods: In a case-crossover study of 192 non-CF bronchiectasis patients with a history of hemoptysis and inhaler use, the risk of hemoptysis associated with the use of inhalers was elucidated. Two inhaled corticosteroids/long-acting β2-agonists (ICS/LABA), one long-acting muscarinic antagonist (LAMA), and one short-acting β2-agonist (SABA) were evaluated. The case and control periods were defined respectively as 0-30 days and 180-210 days before hemoptysis. Results: The risk of hemoptysis during the case period was 3.51 times higher than during the control period with any use of inhalers (95% confidence interval (CI), 1.96-6.28). The results of clinically significant hemoptysis showed good agreement with those of total events. These associations were consistent with the sensitivity analyses. In the sub-analysis according to inhaler type, ICS/LABA and SABA were significantly associated with an increased risk of hemoptysis (aOR 2.62, 95% CI 1.25-5.45 | - |
dc.description.abstract | aOR 2.51, 95% CI 2.23-5.15).
Conclusions: In patients with non-CF bronchiectasis, the use of inhalers, especially including β2-agonist, was associated with an increased risk of hemoptysis. | - |
dc.description.tableofcontents | Abstract........................................i
Contents......................................ii List of tables and figures.............iii List of abbreviations....................iv Introduction.................................1 Methods.....................................2 Results.......................................6 Discussion...............................14 References..............................17 Abstract in Korean....................20 | - |
dc.format | application/pdf | - |
dc.format.extent | 485122 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Bronchiectasis | - |
dc.subject | Hemoptysis | - |
dc.subject | Inhaled corticosteroids | - |
dc.subject | Bronchodilators | - |
dc.subject.ddc | 610 | - |
dc.title | Effect of inhalers on the development of hemoptysis in patients with non-cystic fibrosis bronchiectasis | - |
dc.title.alternative | 기관지확장증 환자에서 흡입기 사용이 객혈 발생에 미치는 영향에 관한 연구 | - |
dc.type | Thesis | - |
dc.description.degree | Master | - |
dc.citation.pages | 20 | - |
dc.contributor.affiliation | 의과대학 임상의과학과 | - |
dc.date.awarded | 2014-02 | - |
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