S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Clinical Medical Sciences (임상의과학과) Theses (Master's Degree_임상의과학과)
Relationship of Serum 25-Hydroxyvitamin D, Parathyroid Hormone with Insulin Resistance and the Impaired Fasting Glucose in Overweight or Obese Children and Adolescents
과체중 또는 비만인 소아청소년에서 비타민D, 부갑상선호르몬과 인슐린 저항성 및 공복혈당장애와의 관련성에 대한 연구
- 의과대학 임상의과학과
- Issue Date
- 서울대학교 대학원
- Parathyroid hormone; PTH; vitamin D; insulin resistance; fasting blood glucose; metabolic syndrome; Korean children
- 학위논문 (석사)-- 서울대학교 대학원 : 임상의과학과, 2016. 2. 신충호.
- Introduction: The nonclassical roles of vitamin D and parathyroid hormone (PTH) in glucose metabolism, insulin resistance, and metabolic syndrome have been proven with increasing evidence in the adult population. However, the role of PTH is controversial and pediatric studies are limited. Therefore, the aim of this study was to examine the association of 25-hydroxyvitamin D [25(OH)D] and PTH levels with insulin resistance, impaired fasting glucose, and metabolic syndrome.
Methods: Obese and overweight children and adolescents that visited Seoul National University Childrens Hospital were enrolled. Correlations between 25(OH)D and PTH levels and HOMA-IR (Homeostasis Model Assessment–Insulin Resistance), fasting glucose, HbA1c, and metabolic syndrome were evaluated by linear regression and logistic regression analysis.
Results: In overweight or obese children and adolescents, adjusting for sex, puberty, and body mass index (BMI) Z-score, 25(OH)D levels were related to HOMA-IR and fasting glucose, independent of PTH levels. PTH levels were related to fasting glucose, although this relationship was not independent of 25(OH)D levels.
Conclusions: This study revealed a significant relationship between vitamin D with fasting glucose and insulin resistance. PTH was correlated with FBG, but this relationship between PTH and fasting glucose was not independent of 25(OH)D.