기관지폐이형성증이 있는 미숙아에서 발생한 폐동맥 고혈압의 장기 결과

Abstract

Background: Infants with bronchopulmonary dysplasia (BPD) are known to have a high risk of pulmonary hypertension (PH). However, the long-term outcomes of PH in preterm infants with BPD are uncertain. The purpose of this study was to assess outcomes of PH in prematurely born children diagnosed with moderate to severe BPD. Methods: We retrospectively reviewed medical records of patients born before 32 weeks gestation and diagnosed with moderate to severe BPD from June 2004 to April 2008. Patients were recruited for a cross-sectional study from August to October 2014 and underwent an echocardiography. Results: Forty-two children were enrolled. Their mean gestational age and birth weight were 26.2 ± 1.7 weeks and 753.1 ± 172.5 g, respectively. Sixteen patients (38%) were diagnosed with PH at a mean age of 3.3 ± 1.6 months, and the PH was improved after a median 12.3 months (range 0.7-46.6 months). Cardiovascular function was reassessed at a mean age of 7.7 ± 0.9 years, at which time 1 patient had been taking a medication for recurrent PH. Conventional two-dimensional and Doppler echocardiography indicated normal ventricular function in all children. However, right ventricular global longitudinal strains decreased in children with previous PH. Conclusions: Subclinical ventricular dysfunction was detectable using sensitive echocardiographic techniques in children with previous BPD-associated PH. Long-term follow-up and meticulous cardiovascular functional assessment is required in this population.