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Epidemiology of Biliary Atresia in Korea
한국의 담도폐쇄증의 역학연구

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Authors
이경재
Advisor
고재성
Major
의과대학 임상의과학과
Issue Date
2017-02
Publisher
서울대학교 대학원
Keywords
Biliary AtresiaIncidenceLiver Transplantation.
Description
학위논문 (석사)-- 서울대학교 대학원 : 임상의과학과, 2017. 2. 고재성.
Abstract
Introduction: Biliary atresia (BA) is the major cause of cholestasis and the leading indication for liver transplantation (LT). However, the incidence of BA in Korea has not been reported. The aim of this study was to investigate the incidence and clinical outcomes of BA in Korea.
Methods: We used the Korean universal health insurance database and extracted data regarding BA patients younger than 18 years of age admitted between 2011 and 2015. The incidence of BA was calculated by dividing the number of BA patients by the number of live births.
Results: Two hundred forty infants were newly diagnosed with BA. A total of 963 BA patients younger than 18 years of age were followed up for 5 years. The overall incidence of BA was 1.06 cases per 10,000 live births. The incidence of BA was 1.4 times higher for female patients than for male patients. Additionally, significant seasonal variation was observed
in particular, the incidence of BA was two times higher from June through August than from December through February. Congenital anomalies were found in 38 out of 240 patients (15.8%). Congenital heart diseases were major associated congenital anomalies (6.3%). Several complications developed during the study period, including cholangitis (24.0%), varix (6.2%) and gastrointestinal bleeding (4.4%). Three hundred one of the 963 BA patients under 18 years of age (31.3%) received LT for BA.
Conclusions: The incidence of BA is higher in Korea than that in Western countries. We also report significant gender-associated differences and seasonal variation with respect to the incidence of BA.
Language
Korean
URI
https://hdl.handle.net/10371/132473
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Clinical Medical Sciences (임상의과학과)Theses (Master's Degree_임상의과학과)
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