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Intraprostatic locations of tumor foci of higher grade missed by diagnostic prostate biopsy among potential candidates for active surveillance
적극적 감시요법의 잠재적 대상자 중 진단적 전립선 조직검사에서 놓친 고등급 종양의 전립선 내 위치

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Authors
김광모
Advisor
홍성규
Major
의과대학 임상의과학과
Issue Date
2017-02
Publisher
서울대학교 대학원
Keywords
prostateprostatic neoplasmsprostate biopsyGleason scorerisk
Description
학위논문 (석사)-- 서울대학교 대학원 : 임상의과학과, 2017. 2. 홍성규.
Abstract
To establish optimal biopsy scheme for selection of candidates for active surveillance (AS) among prostate cancer (PCa) patients, information on topographical distribution of tumor foci of higher grade missed by contemporary biopsy amongst potential candidates of AS would certainly be useful. Thus we analyzed topographic distribution of tumor foci by examining prostatectomy specimens in 444 patients who underwent radical prostatectomy for low risk PCa. Anterior and posterior prostate areas were demarcated by a horizontal line drawn at midpoint of prostatic urethra. Among 444 subjects, patients with upgrading showed relatively higher prevalence of index tumor foci in anterior prostate than those without upgrading, though not reaching statistical significance (p = 0.252). Meanwhile, among 135 (30.4%) patients with very low risk PCa, patients with upgrading showed significantly higher prevalence of index tumor foci in anterior prostate than those without upgrading (52.2% vs 33.8%
p = 0.031). In conclusions, tumor foci of higher grade missed by diagnostic biopsy were mostly located in anterior prostate among very low risk PCa patients. Such finding would be concrete evidence to support the notion that more efforts are needed to increase accuracy in detecting tumor foci in anterior prostate among potential candidates for AS.
Language
Korean
URI
https://hdl.handle.net/10371/132485
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Clinical Medical Sciences (임상의과학과)Theses (Master's Degree_임상의과학과)
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