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Assessing Impact of High-Dose Pitavastatin on Carotid Artery Elasticity with Speckle-Tracking Imaging : 고용량 pitavastatin이 경동맥 탄성에 주는 영향을 반점 추적 영상을 이용하여 분석한 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 김용진 | - |
dc.contributor.author | 김지혜 | - |
dc.date.accessioned | 2017-07-19T10:16:06Z | - |
dc.date.available | 2017-07-19T10:16:06Z | - |
dc.date.issued | 2017-02 | - |
dc.identifier.other | 000000142346 | - |
dc.identifier.uri | https://hdl.handle.net/10371/132494 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 임상의과학과, 2017. 2. 김용진. | - |
dc.description.abstract | Background: Two-dimensional speckle-tracking strain imaging has been introduced for the precise assessment of arterial mechanics. The objective of this study was to evaluate the short-term effects of pitavastatin on carotid artery elasticity measured by speckle tracking methods.
Methods: This study included 30 statin-naïve patients (age, 61.6 ± 7.6 years | - |
dc.description.abstract | 26.7% male) with hypercholesterolemia. Circumferential carotid artery strain (CAS) was measured using speckle-tracking imaging before and after 3 months of high-dose pitavastatin treatment (4 mg daily).
Results: After 3 months, circumferential CAS was significantly increased compared to baseline (from 2.73 ± 1.17% to 3.27 ± 1.53%, p = 0.029). Among conventional carotid elasticity metrics, strain measured by B-mode improved significantly after statin therapy. No significant change in carotid intima-media thickness was observed after pitavastatin treatment (from 0.73 ± 0.18 to 0.71 ± 0.16 mm, p = 0.913). Conclusions: Short-term treatment with high-dose pitavastatin improved carotid artery elasticity measured by speckle-tracking methods. These speckle-tracking imaging-based measurements may allow the early noninvasive assessment of favorable effects of medical intervention in patients with hypercholesterolemia. | - |
dc.description.tableofcontents | Introduction 1
Methods 3 Results 7 Discussion 15 Conclusion 19 References 20 국문초록 24 | - |
dc.format | application/pdf | - |
dc.format.extent | 536920 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | pitavastatin | - |
dc.subject | carotid artery | - |
dc.subject | elasticity | - |
dc.subject | speckle-tracking imaging | - |
dc.subject.ddc | 610 | - |
dc.title | Assessing Impact of High-Dose Pitavastatin on Carotid Artery Elasticity with Speckle-Tracking Imaging | - |
dc.title.alternative | 고용량 pitavastatin이 경동맥 탄성에 주는 영향을 반점 추적 영상을 이용하여 분석한 연구 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | Chee Hae Kim | - |
dc.description.degree | Master | - |
dc.citation.pages | 25 | - |
dc.contributor.affiliation | 의과대학 임상의과학과 | - |
dc.date.awarded | 2017-02 | - |
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