Effects of environmental cadmium exposure on liver function: analysis of KNHANES 2008-2009 data
환경적 카드뮴 노출이 간기능에 미치는 영향: 2008-2009년 국민건강영양조사 자료를 중심으로

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의과대학 의학과
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서울대학교 대학원
CadmiumLiver functionHepatotoxicityEnvironmental exposure
학위논문 (석사)-- 서울대학교 대학원 : 의학과 예방의학 전공, 2013. 2. 홍윤철.
Introduction: There is inconsistency regarding the effects of cadmium exposure on liver function between the positive results found in animal studies and the negative results highlighted in epidemiological studies. We investigated whether environmental cadmium exposure is associated with an elevation in serum liver enzyme activity in Korean adults.

Methods: This cross-sectional study evaluated adult participants without liver disease from the Korean National Health and Nutrition Examination Survey (KNHANES) for 2008–2009. Multiple linear regression was conducted to investigate the association between blood cadmium concentration and the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) adjusting for age, sex, body mass index, supplementary health food and the amount of alcohol consumption. Subjects were stratified into quartiles by their cumulative cadmium exposure rank. We estimated the multivariate-adjusted odds ratios (ORs) for liver enzyme elevation using logistic regression models with the first quartile as the reference group.

Results: Total number of the subjects in the analysis was 3,806. The blood cadmium concentrations were significantly associated with liver enzyme levels (AST, beta=2.844, P-value <.0001
ALT, beta=3.143, P-value <.0001
ALP, beta=8.228, P-value=0.0197). As the cadmium levels approached higher quartiles, the ORs for an elevated AST, ALT and ALP was increased significantly.

Conclusions: Environmental cadmium exposures are associated with an elevation in serum liver enzyme levels in Korean adults.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Theses (Master's Degree_의학과)
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